ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
In vivo oxidative capacity varies with muscle and training status in young adults.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01911091 (Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation in Both Skeletal Muscle and Adipose Tissue), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation in Both Skeletal Muscle and Adipose Tissue
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.The Journal of physiology · 2026Article
- Muscle oxidative capacity does not appear to influence NIRS-VOT outcomes in healthy adults.European journal of applied physiology · 2026Article
- Muscle oxidative capacity but not specific force is greater in aerobic versus resistance trained young adults.European journal of applied physiology · 2025Article
- In vivo imaging of glycogen in human muscle.Nature communications · 2024Article
- Post-exercise intramuscular OThe Journal of physiology · 2021Article
- In vivo assessment of mitochondrial capacity using NIRS in locomotor muscles of young and elderly males with similar physical activity levels.GeroScience · 2020Article
- Early detection of skeletal muscle bioenergetic deficit by magnetic resonance spectroscopy in cigarette smoke-exposed mice.PloS one · 2020Article
- Bioenergetic basis for the increased fatigability with ageing.The Journal of physiology · 2019Article
- Review
- Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.Journal of the American Geriatrics Society · 2019Article
- Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge.BMC molecular and cell biology · 2019Article
- Oxidative capacity varies along the length of healthy human tibialis anterior.The Journal of physiology · 2018Article
- Enhanced Local Skeletal Muscle Oxidative Capacity and Microvascular Blood Flow Following 7-Day Ischemic Preconditioning in Healthy Humans.Frontiers in physiology · 2018Article
- Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function.American journal of physiology. Endocrinology and metabolism · 2016Article
- Mechanisms of in vivo muscle fatigue in humans: investigating age-related fatigue resistance with a computational model.The Journal of physiology · 2016Article
- Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V˙O2peaks.Medicine and science in sports and exercise · 2016Article
- Human skeletal muscle metabolic economy in vivo: effects of contraction intensity, age, and mobility impairment.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- High-intensity interval training alters ATP pathway flux during maximal muscle contractions in humans.Acta physiologica (Oxford, England) · 2014Article
- Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It is well established that exercise training results in increased muscle oxidative capacity. Less is known about how oxidative capacities in distinct muscles, in the same individual, are affected by different levels of physical activity. We hypothesized that 1) trained individuals would have higher oxidative capacity than untrained individuals in both tibialis anterior (TA) and vastus lateralis (VL) and 2) oxidative capacity would be higher in TA than VL in untrained, but not in trained, individuals. Phosphorus magnetic resonance spectroscopy was used to measure the rate of phosphocreatine recovery (k(PCr)), which reflects the rate of oxidative phosphorylation, following a maximal voluntary isometric contraction of the TA and VL in healthy untrained (7 women, 7 men, 25.7 +/- 3.6 yr; mean +/- SD) and trained (5 women, 7 men, 27.5 +/- 3.4 yr) adults. Daily physical activity levels were measured using accelerometry. The trained group spent threefold more time ( approximately 90 vs. approximately 30 min/day; P < 0.001) in moderate to vigorous physical activity (MVPA). Overall, k(PCr) was higher in VL than in TA (P = 0.01) and higher in trained than in untrained participants (P < 0.001). The relationship between k(PCr) and MVPA was more robust in VL (r = 0.64, P = 0.001, n = 25) than in TA (r = 0.38, P = 0.06, n = 25). These results indicate greater oxidative capacity in vivo in trained compared with untrained individuals in two distinct muscles of the lower limb and provide novel evidence of higher oxidative capacity in VL compared with TA in young humans, irrespective of training status. The basis for this difference is not known at this time but likely reflects a difference in usage patterns between the muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.