ArticleJournal of applied physiology (Bethesda, Md. : 1985)2009
Exercise training decreases the size and alters the composition of the neointima in a porcine model of percutaneous transluminal coronary angioplasty (PTCA).
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Exercise-mediated adaptations in vascular function and structure: Beneficial effects in coronary artery disease.World journal of cardiology · 2021Review
- Endurance exercise training does not limit coronary atherosclerosis in familial hypercholesterolemic swine.Physiological reports · 2019Article
- Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exercise.Basic research in cardiology · 2016Article
- The coronary circulation in exercise training.American journal of physiology. Heart and circulatory physiology · 2012Review
- Exercise does not attenuate early CAD progression in a pig model.Medicine and science in sports and exercise · 2012Article
- Ca2+ regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Short-term exercise training prevents micro- and macrovascular disease following coronary stenting.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosis.Cardiovascular research · 2010Article
- Benefits of exercise training on coronary blood flow in coronary artery disease patients.Progress in cardiovascular diseasesReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exercise training (EX) following percutaneous transluminal coronary angiography (PTCA) reduces progression to restenosis and increases event-free survival rates. Our aim was to determine whether EX inhibits lesion development and/or alters the extracellular matrix (ECM) composition of the neointima (NI) in a porcine PTCA model. Miniature Yucatan swine were assigned to cage confinement (SED) or EX for 20 wk. After 16 wk, all animals underwent a PTCA procedure of the left anterior descending artery (LAD) and left circumflex artery (LCX), with subsequent placement of an externalized jugular catheter. Animals recovered for 2 days and then resumed the previous protocol of SED or EX. Twelve days following PTCA, all animals received an intravenous bromodeoxyuridine (BrdU) injection to label proliferating cells. At 28 days following PTCA, the animals were euthanized, the LAD and LCX excised, and underwent standard histological processing for total collagen, type I collagen, fibronectin, BrdU, and Verhoeff-van Gieson stain. Our results demonstrate that EX significantly decreased lesion size and NI proliferation (-48%) in the LAD (P < 0.05) but not the LCX. Furthermore, EX attenuated type I collagen expression only in LAD, whereas total collagen was increased (5.9%) and fibronectin was decreased (-7.9%) in the NI of both vessels (P < 0.05). In conclusion, EX following PTCA may increase event-free survival rates following PTCA by decreasing lesion size and altering ECM composition.
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Registered trials
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