ArticleMicrobiology (Reading, England)2009
Mycobacteriophages BPs, Angel and Halo: comparative genomics reveals a novel class of ultra-small mobile genetic elements.
Article in Microbiology (Reading, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- MosaicLev: modified Levenshtein distance for mobile element-aware genome comparison.Bioinformatics advances · 2026Article
- Genome synthesis, assembly, and rebooting of therapeutically useful high G+C% mycobacteriophages.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mycobacteriophage Yasnaya_Polyana and its engineered lytic derivative: specificity of regulatory motifs and lytic potential.Frontiers in microbiology · 2025Article
- Genome Sequence of Mycobacterium Phage Guppsters.microPublication biology · 2025Article
- Complete Genome Sequences of Mycobacteriophages Balomoji, Crumble, Frederick, ShowerHandel, TinyTimmy and Zabiza.microPublication biology · 2025Article
- Article
- Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates.Nature microbiology · 2023Article
- Virion glycosylation influences mycobacteriophage immune recognition.Cell host & microbe · 2023Article
- Mycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection.Nature microbiology · 2023Article
- Phage Therapy for Nontuberculous Mycobacteria: Challenges and Opportunities.Pulmonary therapy · 2023Review
- Complete Genome Sequences of Cluster F1 Mycobacteriophages Akhila and MilanaBonita.Microbiology resource announcements · 2023Article
- Characterization of the cluster MabR prophages of Mycobacterium abscessus and Mycobacterium chelonae.G3 (Bethesda, Md.) · 2022Article
- A Review on Mycobacteriophages: From Classification to Applications.Pathogens (Basel, Switzerland) · 2022Review
- Mycobacteriophages: From Petri dish to patient.PLoS pathogens · 2022Review
- Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages.BMC microbiology · 2021Article
- Article
- Complete Genome Sequences of Mycobacteriophages HarryOW and Peeb.Microbiology resource announcements · 2021Article
- Phage Therapy for Mycobacterium Abscessus and Strategies to Improve Outcomes.Microorganisms · 2021Review
- Mycobacteriophages.Microbiology spectrum · 2018Review
- A Parallel Adder Coordinates Mycobacterial Cell-Cycle Progression and Cell-Size Homeostasis in the Context of Asymmetric Growth and Organization.Current biology : CB · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Mycobacteriophages BPs, Angel and Halo are closely related viruses isolated from Mycobacterium smegmatis, and possess the smallest known mycobacteriophage genomes, 41,901 bp, 42,289 bp and 41,441 bp, respectively. Comparative genome analysis reveals a novel class of ultra-small mobile genetic elements; BPs and Halo each contain an insertion of the proposed mobile elements MPME1 and MPME2, respectively, at different locations, while Angel contains neither. The close similarity of the genomes provides a comparison of the pre- and post-integration sequences, revealing an unusual 6 bp insertion at one end of the element and no target duplication. Nine additional copies of these mobile elements are identified in a variety of different contexts in other mycobacteriophage genomes. In addition, BPs, Angel and Halo have an unusual lysogeny module in which the repressor and integrase genes are closely linked. The attP site is located within the repressor-coding region, such that prophage formation results in expression of a C-terminally truncated, but active, form of the repressor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.