Trial reportPsychiatry research2009
Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study.
Trial report in Psychiatry research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Glycine Pharmacodynamic Study
Pilot Study of Glycine Augmentation in Carriers of a Mutation in the Gene Encoding Glycine Decarboxylase
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Evaluation of glycine treatment for reducing alcohol craving and self-administration in individuals with alcohol use disorder: A human laboratory trial.Alcohol, clinical & experimental research · 2025Trial
- A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo.npj aging · 2025Article
- Neuron-Specific Glycine Metabolism Links Transfer RNA Epitranscriptomic Regulation to Complex Behaviors.Biological psychiatry global open science · 2025Article
- The glycine-containing dipeptide leucine-glycine raises accumbal dopamine levels in a subpopulation of rats presenting a lower endogenous dopamine tone.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- The potential ofPsychopharmacology · 2021Review
- GlyCEST: Magnetic Resonance Imaging of Glycine-Distribution in the Normal Murine Brain and Alterations in 5xFAD Mice.Contrast media & molecular imaging · 2021Article
- Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder.Neuroscience letters · 2019Article
- Dietary glycine decreases both tumor volume and vascularization in a combined colorectal liver metastasis and chemotherapy model.International journal of biological sciences · 2019Article
- In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T.Biological psychiatry · 2018Article
- EditedMagnetic resonance in medicine · 2017Review
- Neurometabolic abnormalities in schizophrenia and depression observed with magnetic resonance spectroscopy at 7 T.BJPsych open · 2017Article
- In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: application to schizophrenia.Neuroscience and biobehavioral reviews · 2015Review
- Use of proton magnetic resonance spectroscopy in the treatment of psychiatric disorders: a critical update.Dialogues in clinical neuroscience · 2013Review
- Measurement of glycine in gray and white matter in the human brain in vivo by 1H MRS at 7.0 T.Magnetic resonance in medicine · 2012Article
- The glycine deportation system and its pharmacological consequences.Pharmacology & therapeutics · 2012Review
- Measurement of glycine in the human brain in vivo by 1H-MRS at 3 T: application in brain tumors.Magnetic resonance in medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Oral high-dose glycine administration has been used as an adjuvant treatment for schizophrenia to enhance glutamate neurotransmission and mitigate glutamate system hypofunction thought to contribute to the disorder. Prior studies in schizophrenia subjects documented clinical improvements after 2 weeks of oral glycine administration, suggesting that brain glycine levels are sufficiently elevated to evoke a clinical response within that time frame. However, no human study has reported on brain glycine changes induced by its administration. We utilized a noninvasive proton magnetic resonance spectroscopy ((1)H-MRS) technique termed echo time-averaged (TEAV) (1)H-MRS, which permits noninvasive quantification of brain glycine in vivo, to determine whether 2 weeks of oral glycine administration (peak dose of 0.8 g/kg/day) increased brain glycine/creatine (Gly/Cr) ratios in 11 healthy adult men. In scans obtained 17 h after the last glycine dose, brain (Gly/Cr) ratios were significantly increased. The data indicate that it is possible to measure brain glycine changes with proton spectroscopy. Developing a more comprehensive understanding of human brain glycine dynamics may lead to optimized use of glycine site agonists and glycine transporter inhibitors to treat schizophrenia, and possibly to treat other disorders associated with glutamate system dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.