ReviewJournal of the American College of Cardiology2009
Future perspectives for the treatment of pulmonary arterial hypertension.
Review in Journal of the American College of Cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 2, Multi-Center, Open-label, Randomized, Parallel-Dose Study to Determine the Safety and Efficacy of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension (PAH)
A Phase 2, Multicenter, Open-Label Study to Evaluate the Intermediate/Long Term Safety and Efficacy of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension
Who cites it
31 citing papers in PubMed.
- Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling.American journal of translational research · 2021Article
- Current and emerging therapeutic approaches to pulmonary hypertension.Reviews in cardiovascular medicine · 2020Review
- Protective Effects of Different Kinds of Filtered Water on Hypertensive Mouse by Suppressing Oxidative Stress and Inflammation.Oxidative medicine and cellular longevity · 2018Article
- Acute right ventricular failure after orthotopic liver transplantation.Annals of translational medicine · 2018Article
- The Changing Landscape of Pulmonary Arterial Hypertension in 21Acta Cardiologica Sinica · 2017Article
- Nerve distribution of canine pulmonary arteries and potential clinical implications.American journal of translational research · 2016Article
- Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute.Pulmonary circulation · 2015Article
- Risk Factors of Pulmonary Hypertension in Brazilian Patients with Sickle Cell Anemia.PloS one · 2015Article
- Rhodiola: an ordinary plant or a promising future therapy for pulmonary hypertension? a brief review.Pulmonary circulation · 2013Article
- Protection of oral hydrogen water as an antioxidant on pulmonary hypertension.Molecular biology reports · 2013Article
- Assessment and treatment of right ventricular failure.Nature reviews. Cardiology · 2013Review
- Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease.Experimental and clinical cardiology · 2013Article
- Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.The Journal of experimental medicine · 2012Article
- Analysis of endothelin-1 and endothelin-1 receptor A gene polymorphisms in patients with pulmonary arterial hypertension.Internal and emergency medicine · 2012Article
- Protein Arginine Methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders.International journal of molecular sciences · 2012Review
- Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.Circulation · 2012Article
- Pulmonary hypertension in patients with Martorell hypertensive leg ulcer: a case control study.Respiratory research · 2012Article
- Platelets in pulmonary hypertension: a causative role or a simple association?Iranian journal of pediatrics · 2012Article
- Review
- Programmatic change: lung disease research in the era of induced pluripotency.American journal of physiology. Lung cellular and molecular physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Over the past 2 decades, pulmonary arterial hypertension has evolved from a uniformly fatal condition to a chronic, manageable disease in many cases, the result of unparalleled development of new therapies and advances in early diagnosis. However, none of the currently available therapies is curative, so the search for new treatment strategies continues. With a deeper understanding of the genetics and the molecular mechanisms of pulmonary vascular disorders, we are now at the threshold of entering a new therapeutic era. Our working group addressed what can be expected in the near future. The topics span the understanding of genetic variations, novel antiproliferative treatments, the role of stem cells, the right ventricle as a therapeutic target, and strategies and challenges for the translation of novel experimental findings into clinical practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.