ArticleMolecular and cellular neurosciences2009
Sp4-dependent repression of neurotrophin-3 limits dendritic branching.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
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- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
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- Peripheral Neuroinflammation and Pain: How Acute Pain Becomes Chronic.Current neuropharmacology · 2024Review
- Transcriptional regulation of neuronal identity.The European journal of neuroscience · 2022Review
- Environmental enrichment reverses cerebellar impairments caused by prenatal exposure to a synthetic glucocorticoid.AIMS neuroscience · 2022Article
- Article
- Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo.Scientific reports · 2018Article
- Mechanisms regulating dendritic arbor patterning.Cellular and molecular life sciences : CMLS · 2017Review
- Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2015Article
- Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site.Neurobiology of disease · 2015Article
- Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning.Developmental neurobiology · 2015Article
- Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.Science signaling · 2014Article
- Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling.Journal of neurochemistry · 2014Article
- Cell-intrinsic drivers of dendrite morphogenesis.Development (Cambridge, England) · 2013Review
- Neuron-specific specificity protein 4 bigenomically regulates the transcription of all mitochondria- and nucleus-encoded cytochrome c oxidase subunit genes in neurons.Journal of neurochemistry · 2013Article
- TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain.Neuron · 2011Review
- Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish.PloS one · 2011Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Regulation of neuronal gene expression is critical to establish functional connections in the mammalian nervous system. The transcription factor Sp4 regulates dendritic patterning during cerebellar granule neuron development by limiting branching and promoting activity-dependent pruning. Here, we investigate neurotrophin-3 (NT3) as a target gene important for Sp4-dependent dendritic morphogenesis. We found that Sp4 overexpression reduced NT3 promoter activity whereas knockdown of Sp4 increased NT3 promoter activity and mRNA. Moreover, Sp4 bound to the NT3 promoter in vivo, supporting a direct role for Sp4 as a repressor of NT3 expression. Addition of exogenous NT3 promoted dendritic branching in cerebellar granule neurons. Furthermore, sequestering NT3 blocked the continued addition of dendritic branches observed upon Sp4 knockdown, but had no effect on dendrite pruning. These findings demonstrate that, during cerebellar granule neuron development, Sp4-dependent repression of neurotrophin-3 is required to limit dendritic branching and thereby promote acquisition of the mature dendritic pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.