ArticleNeuron2009
Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Heparan sulfate as a central modulator of growth factor dynamics in tissue regeneration.APL bioengineering · 2025Article
- FGF diffusion is required for directed migration of postembryonic muscle progenitors in C. elegans.Development (Cambridge, England) · 2025Article
- Roles of Fibroblast Growth Factors in the Axon Guidance.International journal of molecular sciences · 2023Review
- Coreceptor functions of cell surface heparan sulfate proteoglycans.American journal of physiology. Cell physiology · 2022Review
- Crosstalk of Intercellular Signaling Pathways in the Generation of Midbrain Dopaminergic Neurons In Vivo and from Stem Cells.Journal of developmental biology · 2019Review
- Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus.Development (Cambridge, England) · 2016Article
- Mechanisms of FGF gradient formation during embryogenesis.Seminars in cell & developmental biology · 2016Review
- Heparan sulfate proteoglycans: a sugar code for vertebrate development?Development (Cambridge, England) · 2015Review
- Engrailed homeoproteins in visual system development.Cellular and molecular life sciences : CMLS · 2015Review
- A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain.Development (Cambridge, England) · 2014Article
- Regulation of ephrin-A expression in compressed retinocollicular maps.Developmental neurobiology · 2013Article
- Exploring mechanisms of FGF signalling through the lens of structural biology.Nature reviews. Molecular cell biology · 2013Review
- Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development.Development (Cambridge, England) · 2012Article
- Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Expression of hindbrain boundary markers is regulated by FGF3.Biology open · 2012Article
- FGF8 signaling is chemotactic for cardiac neural crest cells.Developmental biology · 2011Article
- Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary.Development (Cambridge, England) · 2011Article
- FGFs: Neurodevelopment's Jack-of-all-Trades - How Do They Do it?Frontiers in neuroscience · 2011Article
- Wiring the brain: the biology of neuronal guidance.Cold Spring Harbor perspectives in biology · 2010Review
- The development of developmental neuroscience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Graded guidance labels are widely used in neural map formation, but it is not well understood which potential strategy leads to their graded expression. In midbrain tectal map development, FGFs can induce an entire midbrain, but their protein distribution is unclear, nor is it known whether they may act instructively to produce graded gene expression. Using a receptor-alkaline phosphatase fusion probe, we find a long-range posterior > anterior FGF protein gradient spanning the midbrain. Heparan sulfate proteoglycan (HSPG) is required for this gradient. To test whether graded FGF concentrations can instruct graded gene expression, a quantitative tectal explant assay was developed. Engrailed-2 and ephrin-As, normally in posterior > anterior tectal gradients, showed graded upregulation. Moreover, EphAs, normally in anterior > posterior countergradients, showed coordinately graded downregulation. These results provide a mechanism to establish graded mapping labels and more generally provide a developmental strategy to coordinately induce a structure and pattern its cell properties in gradients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.