ArticleBMC cell biology2009
Evidence for a mitochondrial localization of the retinoblastoma protein.
Article in BMC cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression.Cancer immunology research · 2025Article
- Cellular Senescence: A Bridge Between Diabetes and Microangiopathy.Biomolecules · 2024Review
- Methionine Supplementation Alleviates the Germ Cell Apoptosis Increased by Maternal Caffeine Intake in aNutrients · 2024Article
- A highly stable RNA aptamer probe for the retinoblastoma protein in live cells.Chemical science · 2020Article
- Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- In-Depth Bioinformatic Study of the CLDN16 Gene and Protein: Prediction of Subcellular Localization to Mitochondria.Medicina (Kaunas, Lithuania) · 2019Article
- A Code of Mono-phosphorylation Modulates the Function of RB.Molecular cell · 2019Article
- Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation.Cancer science · 2017Review
- Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells.Stem cell reports · 2017Article
- RB1: a prototype tumor suppressor and an enigma.Genes & development · 2016Review
- Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions.Molecular biology of the cell · 2016Article
- Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity.Scientific reports · 2015Article
- Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy.PloS one · 2015Article
- Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Cancer & metabolism · 2014Review
- Phosphorylation of the Retinoblastoma protein (Rb) on serine-807 is required for association with Bax.Cell cycle (Georgetown, Tex.) · 2014Article
- Mutating RBF can enhance its pro-apoptotic activity and uncovers a new role in tissue homeostasis.PloS one · 2014Article
- Mitochondrial dysfunction in cancer.Frontiers in oncology · 2013Review
- Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase.Cell cycle (Georgetown, Tex.) · 2013Article
- The retinoblastoma protein induces apoptosis directly at the mitochondria.Genes & development · 2013Article
- p55PIK transcriptionally activated by MZF1 promotes colorectal cancer cell proliferation.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe retinoblastoma protein (Rb) plays a central role in the regulation of cell cycle, differentiation and apoptosis. In cancer cells, ablation of Rb function or its pathway is a consequence of genetic inactivation, viral oncoprotein binding or deregulated hyperphosphorylation. Some recent data suggest that Rb relocation could also account for the regulation of its tumor suppressor activity, as is the case for other tumor suppressor proteins, such as p53.
resultsIn this reported study, we present evidence that a fraction of the total amount of Rb protein can localize to the mitochondria in proliferative cells taken from both rodent and human cells. This result is also supported by the use of Rb siRNAs, which substantially reduced the amount of mitochondrial Rb, and by acellular assays, in which [35S]-Methionine-labeled Rb proteins bind strongly to mitochondria isolated from rat liver. Moreover, endogenous Rb is found in an internal compartment of the mitochondria, within the inner-membrane. This is consistent with the protection of Rb from alkaline treatment, which destroys any interaction of proteins that are weakly bound to mitochondria.
conclusionAlthough a few data regarding an unspecific cytosolic localization of Rb protein have been reported for some tumor cells, our results are the first evidence of a mitochondrial localization of Rb. The mitochondrial localization of Rb is observed in parallel with its classic nuclear location and paves the way for the study of potential as-yet-unknown roles of Rb at this site.
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