ReviewHead & neck oncology2009
Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review.
Review in Head & neck oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010.Oral oncology · 2011Pooled it
- Alcohol and Tobacco Increases Risk of High Risk HPV Infection in Head and Neck Cancer Patients: Study from North-East Region of India.PloS one · 2015Trial
- Exploring HPV-linked head and neck cancer in Southern Punjab, Pakistan: Insights from HPV-16 phylogenetic analysis.Journal of Taibah University Medical Sciences · 2025Article
- Role of Human Papilloma Virus in the Aetiology of Sinonasal Cancers.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Frequency of HPV in oral cavity squamous cell carcinoma.BMC cancer · 2018Article
- Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer.PloS one · 2018Article
- Review
- Deregulation of SYCP2 predicts early stage human papillomavirus-positive oropharyngeal carcinoma: A prospective whole transcriptome analysis.Cancer science · 2015Article
- NGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome.British journal of cancer · 2015Article
- Prevalence of oral human papilloma virus in healthy individuals in East azerbaijan province of iran.Iranian journal of public health · 2013Article
- Screening and detection of human papillomavirus (HPV) high-risk strains HPV16 and HPV18 in saliva samples from subjects under 18 years old in Nevada: a pilot study.BMC oral health · 2012Article
- Cervical and Oral Screening for HR-HPV types 16 and 18 among Sudanese Women Cervical Lesions.Infectious agents and cancer · 2012Article
- Immunophenotyping of HPV Types 16 and 18 among Sudanese Patients with Oral Lesions.Oman medical journal · 2012Article
- Human papilloma virus in head and neck squamous cell cancer.Iranian journal of cancer prevention · 2012Article
- Squamous cell carcinoma in the larynx in a 7-year-child.Pediatric surgery international · 2011Article
- Immunohistochemical staining of Langerhans cells in HPV-positive and HPV-negative cases of oral squamous cells carcinoma.Journal of applied oral science : revista FOB · 2011Article
- The role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview.Infectious agents and cancer · 2011Article
- Comparative study between the Hybrid Capture II test and PCR based assay for the detection of human papillomavirus DNA in oral submucous fibrosis and oral squamous cell carcinoma.Virology journal · 2010Article
- Detection of human papilloma virus in potentially malignant and malignant lesions of the oral cavity and a study of associated risk factors.South Asian journal of cancerArticle
- p53 polymorphism and association of human papillomavirus in oral submucous fibrosis and oral squamous cell carcinoma: A case-control study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Head and neck malignancies are characterized by a multiphasic and multifactorial etiopathogenesis. Tobacco and alcohol consumption are the most common risk factors for head and neck malignancy. Other factors, including DNA viruses, especially human papilloma virus (HPV), may also play a role in the initiation or development of these lesions. The pathways of HPV transmission in the head and neck mucosal lesions include oral-genital contact, more than one sexual partner and perinatal transmission of HPV to the neonatal child. The increase in prevalence of HPV infection in these lesions may be due to wider acceptance of oral sex among teenagers and adults as this is perceived to be a form of safe sex. The prevalence of HPV in benign lesions as well as malignancies has been assessed by many techniques. Among these, the polymerase chain reaction is the most sensitive method. Review of literature reveals that HPV may be a risk factor for malignancies, but not in all cases. For confirmation of the role of HPV in head and neck squamous cell carcinoma, large population studies are necessary in an assortment of clinical settings. Prophylactic vaccination against high-risk HPV types eventually may prevent a significant number of cervical carcinomas. Of the two vaccines currently available, Gardasil (Merck & Co., Inc.) protects against HPV types 6, 11, 16 and 18, while the other vaccine, Cervarix (GlaxoSmithKline, Rixensart, Belgium) protects against HPV types 16 and 18 only. However, the HPV vaccine has, to the best of our knowledge, not been tried in head and neck carcinoma. The role of HPV in etiopathogenesis, prevalence in benign and malignant lesions of this area and vaccination strategies are briefly reviewed here.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.