ArticleJournal of cellular and molecular medicine2009
Regression and persistence: remodelling in a tissue engineered axial vascular assembly.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04001842 (Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes
Who cites it
15 citing papers in PubMed.
- Vascular persistence following precision micropuncture.Microcirculation (New York, N.Y. : 1994) · 2024Article
- Transluminal Pillars-Their Origin and Role in the Remodelling of the Zebrafish Caudal Vein Plexus.International journal of molecular sciences · 2023Article
- A tissue engineered 3D printed calcium alkali phosphate bioceramic bone graft enables vascularization and regeneration of critical-size discontinuity bony defectsFrontiers in bioengineering and biotechnology · 2023Article
- The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering.Journal of visualized experiments : JoVE · 2016Article
- Vessel transformation in chronic wounds under topical negative pressure therapy: an immunohistochemical analysis.International wound journal · 2015Article
- Tissue engineering and regenerative medicine -where do we stand?Journal of cellular and molecular medicine · 2012Review
- Endothelial progenitor cells are integrated in newly formed capillaries and alter adjacent fibrovascular tissue after subcutaneous implantation in a fibrin matrix.Journal of cellular and molecular medicine · 2011Article
- Wide topical negative pressure wound dressing treatment for patients undergoing abdominal dermolipectomy following massive weight loss.Obesity surgery · 2011Article
- The reconstruction of lung alveolus-like structure in collagen-matrigel/microcapsules scaffolds in vitro.Journal of cellular and molecular medicine · 2011Article
- Changes of anabolic processes at the cellular and molecular level in chronic wounds under topical negative pressure can be revealed by transcriptome analysis.Journal of cellular and molecular medicine · 2011Article
- Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases.Journal of cellular and molecular medicine · 2011Article
- Gene expression analysis of ischaemia and reperfusion in human microsurgical free muscle tissue transfer.Journal of cellular and molecular medicine · 2011Article
- Regenerative medicine: then and now--an update of recent history into future possibilities.Journal of cellular and molecular medicine · 2010Review
- Cell interactions in bone tissue engineering.Journal of cellular and molecular medicine · 2010Review
- [The development of plastic surgery: retrospective view of 80 years of "Der Chirurg" (The Surgeon)].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2009Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In later stages of vasculoangiogenesis a vascular network is going through a metamorphosis for optimal perfusion and economy of energy. In this study we make a quantitative approach to phenomena of remodelling in a bioartificial neovascular network and suggest variance of calibre as a parameter of neovascular maturation. For this study, 18 male Lewis rats were subjected to the AV loop operation in combination with a hard porous biogenic matrix and an isolation chamber. The animals were allocated into three groups for different explantation intervals set to 2, 4 and 8 weeks, respectively. Collective attributes like vascular density, percent fractional area and variance of calibre were evaluated for a predefined region of interest (ROI). Late morphogenesis was evaluated by means of scanning electron microscopy. After the fourth week the absolute number of vessels within the ROI decreased (P < 0.03) whereas, on the contrary, the fractional area of all segments increased (P < 0.02). The variance in calibre was significantly increased in the 8-week group (P < 0.05). Lymphatic growth after week 4, early pericyte migration as well as intussusceptive angiogenesis were identified immunohistologically. Phenomena of remodelling were evaluated quantitatively in a neovascular network and variance could be proposed as a parameter of net vascular maturation.
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