Evidence map›Paper›PMID 19555292›Full record

ReviewAnnual review of neuroscience2009

Advances in light microscopy for neuroscience.

Brian A Wilt, Laurie D Burns, Eric Tatt Wei Ho, Kunal K Ghosh, Eran A Mukamel, Mark J Schnitzer

Abstract readReview
In one paragraph

Review in Annual review of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Modeling nonlinear optical microscopy in scattering media, part I. Propagation from lens to focal volume: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2023
    Article
  11. The temporal and contextual stability of activity levels in hippocampal CA1 cells.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Attractor and integrator networks in the brain.Nature reviews. Neuroscience · 2022
    Review
  18. Article
  19. Article
  20. A diffusion MRI-based spatiotemporal continuum of the embryonic mouse brain for probing gene-neuroanatomy connections.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian A WiltJames H. Clark Center and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA.
Laurie D Burns
Eric Tatt Wei Ho
Kunal K Ghosh
Eran A Mukamel
Mark J Schnitzer

Funding

Massively Parallel Brain ImagingDP1OD003560 · OD · STANFORD UNIVERSITY · PI SCHNITZER, MARK J · 2007 to 2011
$3.9M
Microscopy with micro-optics in deep tissue in vivoR01NS050533 · NINDS · STANFORD UNIVERSITY · PI SCHNITZER, MARK J · 2005 to 2008
$1.8M
Chronic Brain Imaging Using Fluorescence EndoscopyR21DA017895 · NIDA · STANFORD UNIVERSITY · PI SCHNITZER, MARK J · 2003 to 2004
$329k
NIDA NIH HHS R21 DA017895NIH HHS DP1 OD003560NINDS NIH HHS R01 NS050533
6 · The paper itself

Abstract

Since the work of Golgi and Cajal, light microscopy has remained a key tool for neuroscientists to observe cellular properties. Ongoing advances have enabled new experimental capabilities using light to inspect the nervous system across multiple spatial scales, including ultrastructural scales finer than the optical diffraction limit. Other progress permits functional imaging at faster speeds, at greater depths in brain tissue, and over larger tissue volumes than previously possible. Portable, miniaturized fluorescence microscopes now allow brain imaging in freely behaving mice. Complementary progress on animal preparations has enabled imaging in head-restrained behaving animals, as well as time-lapse microscopy studies in the brains of live subjects. Mouse genetic approaches permit mosaic and inducible fluorescence-labeling strategies, whereas intrinsic contrast mechanisms allow in vivo imaging of animals and humans without use of exogenous markers. This review surveys such advances and highlights emerging capabilities of particular interest to neuroscientists.

Indexed as

AnimalsHumansImage CytometryMiceMice, TransgenicMicroscopyMicroscopy, ConfocalMicroscopy, FluorescenceMolecular BiologyNervous SystemNeuronsNeurosciences

Identifiers

PMID19555292
PMCPMC2820375

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.