ReviewAnnual review of neuroscience2009
The neuropsychopharmacology of fronto-executive function: monoaminergic modulation.
Review in Annual review of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01304355 (Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome), which is not on this map. Cited by 472 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression
Who cites it
472 citing papers in PubMed, 5 syntheses or guidelines pooled it, 962 citations in OpenAlex.
- Exergames improve cognitive function in older adults and their possible mechanisms: A systematic review.Journal of global health · 2023Pooled it
- Pooled it
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- Quantifying the inverted U: A meta-analysis of prefrontal dopamine, D1 receptors, and working memory.Behavioral neuroscience · 2022Pooled it
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- GABAergic Modulation of Brain Function During Prosaccade and Antisaccade Eye Movements: Evidence From Ultra-High-Field fMRI.Human brain mapping · 2026Trial
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.Molecular psychiatry · 2026Trial
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson's disease.Communications biology · 2025Trial
- Neurobiological influences on event perception: the role of catecholamines.The international journal of neuropsychopharmacology · 2025Trial
- Auricular Transcutaneous Vagus Nerve Stimulation Specifically Enhances Working Memory Gate Closing Mechanism: A System Neurophysiological Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task.Psychopharmacology · 2022Trial
- Perception-Action Integration Is Modulated by the Catecholaminergic System Depending on Learning Experience.The international journal of neuropsychopharmacology · 2021Trial
- Addiction history moderates the effect of prefrontal 10-Hz transcranial alternating current stimulation on habitual action selection.Journal of neurophysiology · 2021Trial
- Acute and Chronic Effects of Green Oat (Nutrients · 2020Trial
- Learning Experience Reverses Catecholaminergic Effects on Adaptive Behavior.The international journal of neuropsychopharmacology · 2020Trial
- Methylphenidate and galantamine in patients with vascular cognitive impairment-the proof-of-principle study STREAM-VCI.Alzheimer's research & therapy · 2020Trial
- Effects of the monoamine stabilizer (-)OSU6162 on cognitive function in alcohol dependence.Psychopharmacology · 2020Trial
- How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition.Journal of child psychology and psychiatry, and allied disciplines · 2018Trial
412 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
We review the modulatory effects of the catecholamine neurotransmitters noradrenaline and dopamine on prefrontal cortical function. The effects of pharmacologic manipulations of these systems, sometimes in comparison with the indoleamine serotonin (5-HT), on performance on a variety of tasks that tap working memory, attentional-set formation and shifting, reversal learning, and response inhibition are compared in rodents, nonhuman primates, and humans using, in a behavioral context, several techniques ranging from microiontophoresis and single-cell electrophysiological recording to pharmacologic functional magnetic resonance imaging. Dissociable effects of drugs and neurotoxins affecting these monoamine systems suggest new ways of conceptualizing state-dependent fronto-executive functions, with implications for understanding the molecular genetic basis of mental illness and its treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.