ArticleThe Journal of cell biology1991
Slow calcium waves accompany cytokinesis in medaka fish eggs.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 119 citations in OpenAlex.
- Calcium signaling is required for anterior patterning in the mouse embryo.PLoS biology · 2025Article
- Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.PLoS biology · 2025Article
- Regulation of Yeast Cytokinesis by Calcium.Journal of fungi (Basel, Switzerland) · 2025Review
- Deciphering the Calcium Code: A Review of Calcium Activity Analysis Methods Employed to Identify Meaningful Activity in Early Neural Development.Biomolecules · 2024Review
- Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis.Molecular biology of the cell · 2022Article
- Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis.Molecular biology of the cell · 2021Article
- Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo.Development (Cambridge, England) · 2018Article
- Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish.Developmental biology · 2017Article
- Nine unanswered questions about cytokinesis.The Journal of cell biology · 2017Review
- Article
- A new organellar complex in rat sympathetic neurons.PloS one · 2010Article
- Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the zebrafish.Molecular reproduction and development · 2010Review
- Calcium waves.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Calcium signalling during the cleavage period of zebrafish development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- Calcium signalling in early embryos.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- A global, myosin light chain kinase-dependent increase in myosin II contractility accompanies the metaphase-anaphase transition in sea urchin eggs.Molecular biology of the cell · 2006Article
- Calcium at fertilization and in early development.Physiological reviews · 2006Review
- Microdomains bounded by endoplasmic reticulum segregate cell cycle calcium transients in syncytial Drosophila embryos.The Journal of cell biology · 2005Article
- Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivo.The Biochemical journal · 2002Article
- Localized calcium signals along the cleavage furrow of the Xenopus egg are not involved in cytokinesis.Molecular biology of the cell · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Animal cells are cleaved by the formation and contraction of an extremely thin actomyosin band. In most cases this contractile band seems to form synchronously around the whole equator of the cleaving cell; however in giant cells it first forms near the mitotic apparatus and then slowly grows outwards over the cell. We studied the relationship of calcium to such contractile band growth using aequorin injected medaka fish eggs: we see two successive waves of faint luminescence moving along each of the first three cleavage furrows at approximately 0.5 micron/s. The first, narrower waves accompany furrow extension, while the second, broader ones, accompany the subsequent apposition or slow zipping together of the separating cells. If the first waves travel within the assembling contractile band, they would indicate local increases of free calcium to concentrations of about five to eight micromolar. This is the first report to visualize high free calcium within cleavage furrows. Moreover, this is also the first report to visualize slow (0.3-1.0 micron/s) as opposed to fast (10-100 microns/s) calcium waves. We suggest that these first waves are needed for furrow growth; that in part they further furrow growth by speeding actomyosin filament shortening, while such shortening in turn acts to mechanically release calcium and thus propagates these waves as well as furrow growth. We also suggest that the second waves act to induce the exocytosis which provides new furrow membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.