Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2009
Variability in depressive symptoms predicts cognitive decline in age-related macular degeneration.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- [The influence of visual rehabilitation on secondary depressive disorders due to age-related macular degeneration. A randomized controlled pilot study].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2013Trial
- Differences in verbal memory performance in postmenopausal women receiving hormone therapy: 17β-estradiol versus conjugated equine estrogens.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2011Trial
- Continuous remote monitoring of neurophysiologic Immersion accurately predicts mood.Frontiers in digital health · 2024Article
- Using digital phenotyping to capture depression symptom variability: detecting naturalistic variability in depression symptoms across one year using passively collected wearable movement and sleep data.Translational psychiatry · 2023Article
- Daily Stressors, Emotion Dynamics, and Inflammation in the MIDUS Cohort.International journal of behavioral medicine · 2022Article
- Comparing Variability, Severity, and Persistence of Depressive Symptoms as Predictors of Future Stroke Risk.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- The psychological challenge of late-life vision impairment: concepts, findings, and practical implications.Journal of ophthalmology · 2013Article
- Longitudinal stability of subsyndromal symptoms of depression in individuals with mild cognitive impairment: relationship to conversion to dementia after 3 years.International journal of geriatric psychiatry · 2012Article
- Depression and cognitive impairment in older adult emergency department patients: changes over 2 weeks.Journal of the American Geriatrics Society · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe measurement of affective symptoms in older persons who decline cognitively is uncertain. The authors investigated whether mood variability predicts dementia in patients with age-related macular degeneration (AMD).
designThree-year observational study after a clinical trial.
settingCommunity follow-up of outpatients ascertained from retina clinics.
participantsOne hundred sixty patients with AMD. MEASUREMENTS: Geriatric Depression Scale (GDS) administered every 2 weeks for 6 months to subjects; Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) administered to subjects' knowledgeable informants.
resultsTwenty-three subjects (14.4%) declined cognitively. Age, education, baseline GDS score > or =5, and variability in GDS scores (i.e., fluctuations between adjacent time points) were associated with cognitive decline. For GDS variability, each 1 unit increase in the residual standard deviation (SD) of the GDS increased the risk for cognitive decline by 93% (IDR = 1.92; 95% CI [1.27-2.91]). Thus, subjects with a residual SD of 1 were nearly twice as likely to become demented as subjects with no variability in GDS scores. The risk for subjects with SDs of 2 increased more than threefold (IDR = 3.68; 95% CI [1.61-8.47]). A multiple regression analysis showed that GDS variability was a significant risk factor for dementia after controlling for significant covariates.
conclusionThese data suggest a useful approach to conceptualizing and measuring depressive symptoms in older persons. Variability in self-reported mood may be an early sign of dementia and may offer new insights into the neurobiological mechanisms linking depression and cognition
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.