ArticleProtein science : a publication of the Protein Society2009
Solution structure of the phytotoxic protein PcF: the first characterized member of the Phytophthora PcF toxin family.
Article in Protein science : a publication of the Protein Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Electron currents mediated by tonoplast cytochromes b561.European biophysics journal : EBJ · 2026Review
- New potential antimicrobial peptides with mirror-symmetrical structure in fungi and insects.Frontiers in microbiology · 2026Article
- The Two-Pore Channel 2 in Human Physiology and Diseases: Functional Characterisation and Pharmacology.International journal of molecular sciences · 2025Review
- The devastating oomycete phytopathogen Phytophthora cactorum: Insights into its biology and molecular features.Molecular plant pathology · 2023Review
- Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic OomycetePlants (Basel, Switzerland) · 2023Article
- Current Methods to Unravel the Functional Properties of Lysosomal Ion Channels and Transporters.Cells · 2022Review
- Transcription profiling and identification of infection-related genes in Phytophthora cactorum.Molecular genetics and genomics : MGG · 2018Article
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
- The Comparison of Expressed Candidate Secreted Proteins from Two Arbuscular Mycorrhizal Fungi Unravels Common and Specific Molecular Tools to Invade Different Host Plants.Frontiers in plant science · 2017Article
- SCR96, a small cysteine-rich secretory protein of Phytophthora cactorum, can trigger cell death in the Solanaceae and is important for pathogenicity and oxidative stress tolerance.Molecular plant pathology · 2016Article
- Transcriptomic analysis of the phytopathogenic oomycete Phytophthora cactorum provides insights into infection-related effectors.BMC genomics · 2014Article
- Structural similarity between defense peptide from wheat and scorpion neurotoxin permits rational functional design.The Journal of biological chemistry · 2014Article
- Comparative structural and functional characterization of putative protein effectors belonging to the PcF toxin family from Phytophthora spp.Protein science : a publication of the Protein Society · 2011Article
- Identification and analysis of Phytophthora cactorum genes up-regulated during cyst germination and strawberry infection.Current genetics · 2011Article
- Disulfide-stabilized helical hairpin structure and activity of a novel antifungal peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli).The Journal of biological chemistry · 2011Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The PcF protein from Phytophthora cactorum is the first member of the "PcF toxin family" from the plant pathogens Phytophthora spp. It is able to induce withering in tomato and strawberry leaves. The lack of sequence similarity with other proteins hampers the identification of the molecular mechanisms responsible for its toxicity. Here, we show that the six cysteines form a disulphide pattern that is exclusive for PcF and essential for the protein withering activity. The NMR solution structure identifies a novel fold among protein effectors: a helix-loop-helix motif. The presence of a negatively charged surface suggests that it might act as a site of electrostatic interaction. Interestingly, a good fold match with Ole e 6, a plant protein with allergenic activity, highlighted the spatial superimposition of a stretch of identical residues. This finding suggests a possible biological activity based on molecular mimicry.
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