ArticleJournal of molecular evolution2009
Aplysia cys-loop glutamate-gated chloride channels reveal convergent evolution of ligand specificity.
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics.Ecotoxicology (London, England) · 2011Pooled it
- Functional Analysis of Ligand-Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila.Neuroscience bulletin · 2025Article
- Evolution of glutamatergic signaling and synapses.Neuropharmacology · 2021Review
- Neural Ganglia Transcriptome and Peptidome Associated with Sexual Maturation in Female Pacific Abalone (Genes · 2019Article
- Abamectin treatment affects glutamate decarboxylase expression and induces higher GABA levels in the citrus red mite, Panonychus citri.Experimental & applied acarology · 2017Article
- Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Scientific reports · 2017Article
- Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Frontiers in molecular neuroscience · 2017Article
- Immunochemical Localization of GABANeurochemical research · 2016Article
- Complex Homology and the Evolution of Nervous Systems.Trends in ecology & evolution · 2016Review
- Article
- Convergence of ion channel genome content in early animal evolution.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.Scientific reports · 2015Article
- Sequence Analysis of Insecticide Action and Detoxification-Related Genes in the Insect Pest Natural Enemy Pardosa pseudoannulata.PloS one · 2015Article
- Article
- Article
- Principles of agonist recognition in Cys-loop receptors.Frontiers in physiology · 2014Review
- Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni.PLoS pathogens · 2013Article
- Glutamate-gated chloride channels.The Journal of biological chemistry · 2012Review
- Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.Frontiers in molecular neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the members of the superfamily of cys-loop ligand-gated ion channels (LGICs) are receptors distinguished by the presence of two cys-loops in the ligand-binding domain, for example, the glycine receptor. Such receptors have thus far been cloned only from vertebrates and from ecdysozoa (arthropods and nematodes). We have now cloned and expressed two 2-cys-loop receptors from Aplysia californica, a lophotrocozoan, and have shown that they form homomeric glutamate receptors. We have also built up a database including the two receptors cloned here, previously cloned vertebrate and ecdysozoan 2-cys-loop receptors taken from GenBank, and the same type of receptors obtained by a search of recently cloned genomes, including two non-vertebrate chordates, an echinoderm, a crustacean, an annelid, and another mollusk. We subjected these receptors to phylogenetic analysis, alone and in combination with GABA-A receptors from the same phyla and from a recently cloned cnidarian. The phylogenetic analysis revealed the presence of two independent clades of glutamate receptors: one from lophotrocozoa and other from ecdysozoa, and suggests that the ancestors of the current 2-cys-loop receptor types diverged from the GABA-A receptors and from each other before the bilateria-cnidaria split. Finally, combining the results from the phylogenetic analysis with those obtained from an analysis of the 2-cys-loop receptors in light of recently published hypotheses concerning the glycine binding pocket, we predict that glycine receptors are not exclusively a vertebrate-receptor type.
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