ArticleThe Journal of biological chemistry2009
Crystal structure of the LG1-3 region of the laminin alpha2 chain.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Characterization of Usher Syndrome Type 2-Associated Proteins in the Retina via Affinity Purification-Mass Spectrometry.Molecular & cellular proteomics : MCP · 2026Article
- Observing Dynamic Conformational Changes within the Coiled-Coil Domain of Different Laminin Isoforms Using High-Speed Atomic Force Microscopy.International journal of molecular sciences · 2024Article
- Evidence of Two NovelFrontiers in neurology · 2022Article
- Design of a specific peptide against phenolic glycolipid-1 from Mycobacterium leprae and its implications in leprosy bacilli entry.Memorias do Instituto Oswaldo Cruz · 2022Article
- Structural modeling, mutation analysis, andComputational and structural biotechnology journal · 2020Article
- Structural biology of laminins.Essays in biochemistry · 2019Review
- Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains.Frontiers in molecular biosciences · 2019Review
- Mechanistic basis for the recognition of laminin-511 by α6β1 integrin.Science advances · 2017Article
- Crystal Structure of the Heterotrimeric Integrin-Binding Region of Laminin-111.Structure (London, England : 1993) · 2017Article
- Cross-linking reveals laminin coiled-coil architecture.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- In silico modeling of the immune system: cellular and molecular scale approaches.BioMed research international · 2014Review
- Determinants of laminin polymerization revealed by the structure of the α5 chain amino-terminal region.EMBO reports · 2011Article
- Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.Journal of cellular physiology · 2010Article
- Laminins in basement membrane assembly.Cell adhesion & migrationReview
- The myotomal basement membrane: insight into laminin-111 function and its control by Sonic hedgehog signaling.Cell adhesion & migrationReview
- Laminin 332 processing impacts cellular behavior.Cell adhesion & migrationReview
- The laminin family.Cell adhesion & migrationReview
- Laminin-211 in skeletal muscle function.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Laminins are large heterotrimeric glycoproteins with many essential functions in basement membrane assembly and function. Cell adhesion to laminins is mediated by a tandem of five laminin G-like (LG) domains at the C terminus of the alpha chain. Integrin binding requires an intact LG1-3 region, as well as contributions from the coiled coil formed by the alpha, beta, and gamma chains. We have determined the crystal structure at 2.8-A resolution of the LG1-3 region of the laminin alpha2 chain (alpha 2LG1-3). The three LG domains adopt typical beta-sandwich folds, with canonical calcium binding sites in LG1 and LG2. LG2 and LG3 interact through a substantial interface, but LG1 is completely dissociated from the LG2-3 pair. We suggest that the missing gamma chain tail may be required to stabilize the interaction between LG1 and LG2-3 in the biologically active conformation. A global analysis of N-linked glycosylation sites shows that the beta-sandwich faces of LG1 are free of carbohydrate modifications in all five laminin alpha chains, suggesting that these surfaces may harbor the integrin binding site. The alpha 2LG1-3 structure provides the first atomic view of the integrin binding region of laminins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.