ArticleJournal of neurophysiology2009
Intrinsic membrane properties and inhibitory synaptic input of kenyon cells as mechanisms for sparse coding?
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 66 citations in OpenAlex.
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- Minimal circuit motifs for second-order conditioning in the insect mushroom body.Frontiers in physiology · 2023Article
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- A spiking neural program for sensorimotor control during foraging in flying insects.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Separate But Interactive Parallel Olfactory Processing Streams Governed by Different Types of GABAergic Feedback Neurons in the Mushroom Body of a Basal Insect.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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- Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory inFrontiers in cellular neuroscience · 2018Article
- In-situ recording of ionic currents in projection neurons and Kenyon cells in the olfactory pathway of the honeybee.PloS one · 2018Article
- Adaptive responses of peripheral lateral line nerve fibres to sinusoidal wave stimuli.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Honeybee locomotion is impaired by Am-CaScientific reports · 2017Article
- Two Parallel Olfactory Pathways for Processing General Odors in a Cockroach.Frontiers in neural circuits · 2017Article
- Oscillatory integration windows in neurons.Nature communications · 2016Article
- Unexpected plant odor responses in a moth pheromone system.Frontiers in physiology · 2015Article
- It takes two-coincidence coding within the dual olfactory pathway of the honeybee.Frontiers in physiology · 2015Article
- Central processing in the mushroom bodies.Current opinion in insect science · 2014Article
- Honeybee Kenyon cells are regulated by a tonic GABA receptor conductance.Journal of neurophysiology · 2014Article
- A temporal channel for information in sparse sensory coding.Current biology : CB · 2014Article
- Effect of GABAergic inhibition on odorant concentration coding in mushroom body intrinsic neurons of the honeybee.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
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Abstract
The insect mushroom bodies (MBs) are multimodal signal processing centers and are essential for olfactory learning. Electrophysiological recordings from the MBs' principal component neurons, the Kenyon cells (KCs), showed a sparse representation of olfactory signals. It has been proposed that the intrinsic and synaptic properties of the KC circuitry combine to reduce the firing of action potentials and to generate relatively brief windows for synaptic integration in the KCs, thus causing them to operate as coincidence detectors. To better understand the ionic mechanisms that mediate the KC intrinsic firing properties, we used whole cell patch-clamp recordings from KCs in the adult, intact brain of Periplaneta americana to analyze voltage- and/or Ca2+-dependent inward (ICa, INa) and outward currents [IA, IK(V), IK,ST, IO(Ca)]. In general the currents had properties similar to those of currents in other insect neurons. Certain functional parameters of ICa and IO(Ca), however, had unusually high values, allowing them to assist sparse coding. ICa had a low-activation threshold and a very high current density compared with those of ICa in other insect neurons. Together these parameters make ICa suitable for boosting and sharpening the excitatory postsynaptic potentials as reported in previous studies. IO(Ca) also had a large current density and a very depolarized activation threshold. In combination, the large ICa and IO(Ca) are likely to mediate the strong spike frequency adaptation. These intrinsic properties of the KCs are likely to be supported by their tonic, inhibitory synaptic input, which was revealed by specific GABA antagonists and which contributes significantly to the hyperpolarized membrane potential at rest.
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