ArticleLearning & memory (Cold Spring Harbor, N.Y.)2009
Odor-specific habituation arises from interaction of afferent synaptic adaptation and intrinsic synaptic potentiation in olfactory cortex.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
- Experience and behavior modulate piriform cortex odor representation in freely moving mice.iScience · 2026Article
- Plasticity in inhibitory networks improves pattern separation in early olfactory processing.Communications biology · 2025Article
- Odor habituation can modulate very early olfactory event-related potential.Scientific reports · 2020Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Habituation as a neural algorithm for online odor discrimination.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Glutamatergic Neurons in the Piriform Cortex Influence the Activity of D1- and D2-Type Receptor-Expressing Olfactory Tubercle Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases.Neurobiology of disease · 2018Article
- BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Granule cell excitability regulates gamma and beta oscillations in a model of the olfactory bulb dendrodendritic microcircuit.Journal of neurophysiology · 2016Article
- Internal Cholinergic Regulation of Learning and Recall in a Model of Olfactory Processing.Frontiers in cellular neuroscience · 2016Article
- A Mathematical Model of the Olfactory Bulb for the Selective Adaptation Mechanism in the Rodent Olfactory System.PloS one · 2016Article
- Coding of odor stimulus features among secondary olfactory structures.Journal of neurophysiology · 2015Article
- Differential modifications of synaptic weights during odor rule learning: dynamics of interaction between the piriform cortex with lower and higher brain areas.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Neonatal representation of odour objects: distinct memories of the whole and its parts.Proceedings. Biological sciences · 2014Article
- Distinct roles of bulbar muscarinic and nicotinic receptors in olfactory discrimination learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Slow-wave sleep-imposed replay modulates both strength and precision of memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease.PloS one · 2014Article
- A spiking neural network model of self-organized pattern recognition in the early mammalian olfactory system.Frontiers in neural circuits · 2014Article
- Sleep and olfactory cortical plasticity.Frontiers in behavioral neuroscience · 2014Review
- A computational framework for understanding decision making through integration of basic learning rules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Segmentation of target odorants from background odorants is a fundamental computational requirement for the olfactory system and is thought to be behaviorally mediated by olfactory habituation memory. Data from our laboratory have shown that odor-specific adaptation in piriform neurons, mediated at least partially by synaptic adaptation between the olfactory bulb outputs and piriform cortex pyramidal cells, is highly odor specific, while that observed at the synaptic level is specific only to certain odor features. Behavioral data show that odor habituation memory at short time constants corresponding to synaptic adaptation is also highly odor specific and is blocked by the same pharmacological agents as synaptic adaptation. Using previously developed computational models of the olfactory system we show here how synaptic adaptation and potentiation interact to create the observed specificity of response adaptation. The model analyzes the mechanisms underlying the odor specificity of habituation, the dependence on functioning cholinergic modulation, and makes predictions about connectivity to and within the piriform neural network. Predictions made by the model for the role of cholinergic modulation are supported by behavioral results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.