Evidence map›Paper›PMID 19553309›Full record

ArticleJournal of virology2009

Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene.

Christopher M Robinson, Jaya Rajaiya, Michael P Walsh, Donald Seto, David W Dyer, Morris S Jones, James Chodosh

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 50 citations in OpenAlex.

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  14. Oncolytic viruses: From bench to bedside with a focus on safety.Human vaccines & immunotherapeutics · 2015
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Christopher M RobinsonDepartment of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.
Jaya Rajaiya
Michael P Walsh
Donald Seto
David W Dyer
Morris S Jones
James Chodosh
George Mason University · USHarvard University · USDavid Grant USAF Medical Center · USMassachusetts Eye and Ear Infirmary · USUniversity of Oklahoma Health Sciences Center · US

Funding

Immunopathogenesis of Adenovirus KeratitisR01EY013124 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James Chodosh, Jaya Rajaiya · 2001 to 2026
$10.8M
NEI NIH HHS R01 EY013124
6 · The paper itself

Abstract

Recombination in human adenoviruses (HAdV) may confer virulence upon an otherwise nonvirulent strain. The genome sequence of species D HAdV type 22 (HAdV-D22) revealed evidence for recombination with HAdV-D19 and HAdV-D37 within the capsid penton base gene. Bootscan analysis demonstrated that recombination sites within the penton base gene frame the coding sequences for the two external hypervariable loops in the protein. A similar pattern of recombination was evident within other HAdV-D types but not other HAdV species. Further study of recombination among HAdVs is needed to better predict possible recombination events among wild-type viruses and adenoviral gene therapy vectors.

Indexed as

Recombination, GeneticAdenoviruses, HumanBase SequenceCapsid ProteinsCluster AnalysisDNA, ViralEvolution, MolecularHumansMolecular Sequence DataPhylogenySequence Analysis, DNASequence HomologyCapsid ProteinsDNA, Viralpenton protein, adenovirus

Identifiers

PMID19553309
PMCPMC2738150
OpenAlexW2155439288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.