ArticleDevelopment (Cambridge, England)2009
Lunatic fringe promotes the lateral inhibition of neurogenesis.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe.Developmental cell · 2026Article
- Neurotrophic Modulation Restores Motor and Developmental Defects in Zebrafish Models of ints11 Deficiency.Journal of neurochemistry · 2026Article
- Glycosylation Pathways Targeted by Deregulated miRNAs in Autism Spectrum Disorder.International journal of molecular sciences · 2025Article
- Her9 controls the stemness properties of hindbrain boundary cells.Development (Cambridge, England) · 2025Article
- Hindbrain boundaries as niches of neural progenitor and stem cells regulated by the extracellular matrix proteoglycan chondroitin sulphate.Development (Cambridge, England) · 2024Article
- Hindbrain rhombomere centers harbor a heterogenous population of dividing progenitors which rely on Notch signaling.Frontiers in cell and developmental biology · 2023Article
- Article
- Retinal regeneration requires dynamic Notch signaling.Neural regeneration research · 2022Review
- Article
- Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish.Theranostics · 2021Article
- The interplay of atoh1 genes in the lower rhombic lip during hindbrain morphogenesis.PloS one · 2020Article
- Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.eLife · 2017Article
- The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes.Open biology · 2017Article
- Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration.BMC biology · 2015Article
- Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Dynamic properties of the segmentation clock mediated by microRNA.International journal of clinical and experimental pathology · 2015Article
- Cell segregation in the vertebrate hindbrain relies on actomyosin cables located at the interhombomeric boundaries.The EMBO journal · 2014Article
- Article
- Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish.BMC biology · 2013Article
- A 380-kb Duplication in 7p22.3 Encompassing the LFNG Gene in a Boy with Asperger Syndrome.Molecular syndromology · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have identified roles of the modulation of Notch activation by Fringe homologues in boundary formation and in regulating the differentiation of vertebrate thymocytes and Drosophila glial cells. We have investigated the role of Lunatic fringe (Lfng) expression during neurogenesis in the vertebrate neural tube. We find that in the zebrafish hindbrain, Lfng is expressed by progenitors in neurogenic regions and downregulated in cells that have initiated neuronal differentiation. Lfng is required cell autonomously in neural epithelial cells to limit the amount of neurogenesis and to maintain progenitors. By contrast, Lfng is not required for the role of Notch in interneuronal fate choice, which we show is mediated by Notch1a. The expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors. These findings suggest that Lfng acts in a feedback loop downstream of proneural genes, which, by promoting Notch activation, maintains the sensitivity of progenitors to lateral inhibition and thus limits further proneural upregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.