ArticleProceedings of the National Academy of Sciences of the United States of America2009
APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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97 citing papers in PubMed, 176 citations in OpenAlex.
- EdU-Based Quantitative Analysis of Cell Proliferation in Arabidopsis Root Meristems.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
- 5-Aminolevulinic acid promotes cell division and young fruit development by suppressing the PpARF9-PpGH3.1 auxin-conjugation module in peach.Molecular horticulture · 2026Article
- Molecular regulation of plant endoreduplication: core mechanisms and their upstream control.Plant molecular biology · 2026Review
- Somatic genome-doubling is the most parsimonious route to allopolyploidy.The New phytologist · 2026Review
- Identification and functional evaluation of cyclin-dependent kinase genes reveals that CDKB1;1 and CDKB2;2 contribute to the balance of mitosis and endoreduplication in Medicago truncatula nodule.BMC plant biology · 2025Article
- Diverse triggers, common outcome: Senescence in Fix⁻ Medicago truncatula nodules.Plant physiology · 2025Article
- The endocycle regulators SIM and CCS52A1 control Arabidopsis root hair cell ploidy and expansion.Plant physiology · 2025Article
- SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.Journal of plant research · 2025Article
- Folate depletion impact on the cell cycle results in restricted primary root growth in Arabidopsis.Plant molecular biology · 2025Article
- Meiotic double-strand break repair DNA synthesis tracts in Arabidopsis thaliana.PLoS genetics · 2024Article
- The canonical E2Fs together with RETINOBLASTOMA-RELATED are required to establish quiescence during plant development.Communications biology · 2023Article
- Plant lineage-specific PIKMIN1 drives APC/CCCS52A2 E3-ligase activity-dependent cell division.Plant physiology · 2023Article
- Keeping quiet: cell cycle regulator PIKMIN1 helps maintain the quiescent center.Plant physiology · 2023Article
- What Can Boron Deficiency Symptoms Tell Us about Its Function and Regulation?Plants (Basel, Switzerland) · 2023Review
- Endoreplication mediates cell size control via mechanochemical signaling from cell wall.Science advances · 2022Article
- A mutation in THREONINE SYNTHASE 1 uncouples proliferation and transition domains of the root apical meristem: experimental evidence and in silico proposed mechanism.Development (Cambridge, England) · 2022Article
- SCFMolecules and cells · 2022Article
- Emerging roles of the ubiquitin-proteasome pathway in enhancing crop yield by optimizing seed agronomic traits.Plant cell reports · 2022Review
- SAMBA controls cell division rate during maize development.Plant physiology · 2022Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant organs originate from meristems where stem cells are maintained to produce continuously daughter cells that are the source of different cell types. The cell cycle switch gene CCS52A, a substrate specific activator of the anaphase promoting complex/cyclosome (APC/C), controls the mitotic arrest and the transition of mitotic cycles to endoreduplication (ER) cycles as part of cell differentiation. Arabidopsis, unlike other organisms, contains 2 CCS52A isoforms. Here, we show that both of them are active and regulate meristem maintenance in the root tip, although through different mechanisms. The CCS52A1 activity in the elongation zone of the root stimulates ER and mitotic exit, and contributes to the border delineation between dividing and expanding cells. In contrast, CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance. Cell proliferation assays in roots suggest that this control involves CCS52A2 mediated repression of mitotic activity in the QC cells. The data indicate that the CCS52A genes favor a low mitotic state in different cell types of the root tip that is required for meristem maintenance, and reveal a previously undescribed mechanism for APC/C mediated control in plant development.
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