ArticleBMC pediatrics2009
Trends in broad-spectrum antibiotic prescribing for children with acute otitis media in the United States, 1998-2004.
Article in BMC pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Antibiotics for preventing suppurative complications from undifferentiated acute respiratory infections in children under five years of age.The Cochrane database of systematic reviews · 2016Pooled it
- Race/Ethnicity and overuse of care: a systematic review.The Milbank quarterly · 2015Pooled it
- Trial
- Interventions to Minimize Unnecessary Antibiotic Use for Acute Otitis Media: A Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Health Equity and Antibiotic Prescribing in the United States: A Systematic Scoping Review.Open forum infectious diseases · 2023Article
- A scoping review and behavioural analysis of factors underlying overuse of antimicrobials.JAC-antimicrobial resistance · 2023Article
- Acute Otitis Media in Children-Challenges of Antibiotic Resistance in the Post-Vaccination Era.Microorganisms · 2022Article
- Patterns of antibiotic use, knowledge, and perceptions among different population categories: A comprehensive study based in Arabic countries.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- In vitro Inhibition of Clinical Isolates of Otitis Media Pathogens by the Probiotic Streptococcus salivarius BLIS K12.Probiotics and antimicrobial proteins · 2021Article
- Socioeconomic Status and Determinants of Pediatric Antibiotic Use.Clinical pediatrics · 2021Article
- Community-level consumption of antibiotics according to the AWaRe (Access, Watch, Reserve) classification in rural Vietnam.JAC-antimicrobial resistance · 2020Article
- Selective pressure: Rise of the nonencapsulated pneumococcus.PLoS pathogens · 2019Article
- Antibiotic prescription in the outpatient paediatric population attending emergency departments in Lombardy, Italy: a retrospective database review.BMJ paediatrics open · 2019Article
- Changes in Outpatient Use of Antibiotics by Adults in the United States, 2006-2015.Drug safety · 2018Observational
- Burden and Risk Factors of Antimicrobial Use in Children Less Than 5 Years of Age with Diarrheal Illness in Rural Bangladesh.The American journal of tropical medicine and hygiene · 2018Article
- Article
- Factors Associated with Prescribing Broad-Spectrum Antibiotics for Children with Upper Respiratory Tract Infections in Ambulatory Care Settings.Clinical medicine insights. Pediatrics · 2018Article
- Antibiotic Use in Febrile Children Presenting to the Emergency Department: A Systematic Review.Frontiers in pediatrics · 2018Article
- Toward Improving Medication Adherence: The Suppression of Bitter Taste in Edible Taste Films.Advances in pharmacological sciences · 2018Article
- Antibiotic prescription and food allergy in young children.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundOveruse of broad-spectrum antibiotics is associated with antibiotic resistance. Acute otitis media (AOM) is responsible for a large proportion of antibiotics prescribed for US children. Rates of broad-spectrum antibiotic prescribing for AOM are unknown.
methodsAnalysis of the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey, 1998 to 2004 (N = 6,878). Setting is office-based physicians, hospital outpatient departments, and emergency departments. Patients are children aged 12 years and younger prescribed antibiotics for acute otitis media. Main outcome measure is percentage of broad-spectrum antibiotics, defined as amoxicillin/clavulanate, macrolides, cephalosporins and quinolones.
resultsBroad-spectrum prescribing for acute otitis media increased from 34% of visits in 1998 to 45% of visits in 2004 (P < .001 for trend). The trend was primarily attributable to an increase in prescribing of amoxicillin/clavulanate (8% to 15%; P < .001 for trend) and macrolides (9% to 15%; P < .001 for trend). Prescribing remained stable for amoxicillin and cephalosporins while decreasing for narrow-spectrum agents (12% to 3%; P < .001 for trend) over the study period. Independent predictors of broad-spectrum antibiotic prescribing were ear pain, non-white race, public and other insurance (compared to private), hospital outpatient department setting, emergency department setting, and West region (compared to South and Midwest regions), each of which was associated with lower rates of broad-spectrum prescribing. Age and fever were not associated with prescribing choice.
conclusionPrescribing of broad-spectrum antibiotics for acute otitis media has steadily increased from 1998 to 2004. Associations with non-clinical factors suggest potential for improvement in prescribing practice.
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