ArticleReproductive biology and endocrinology : RB&E2009
Chronic crude garlic-feeding modified adult male rat testicular markers: mechanisms of action.
Article in Reproductive biology and endocrinology : RB&E, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Evaluation of Expression of Cytochrome P450 Aromatase and Inflammatory, Oxidative, and Apoptotic Markers in Testicular Tissue of Obese Rats (Pre)Treated with Garlic Powder.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Modulatory effects of R10 fraction of garlic (Allium sativum L.) on hormonal levels, T cell polarization, and fertility-related genes in mice model of polycystic ovarian syndrome.Journal of ovarian research · 2022Article
- Modulatory role of garlic (F1000Research · 2022Article
- A Comparative study on the effects of Yaji (Suya Meat sauce) and its spice constituents on the male reproductive profile of adult male Sprague Dawley rats.JBRA assisted reproduction · 2021Article
- Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia.Scientific reports · 2021Article
- Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development.BMC complementary medicine and therapies · 2021Article
- Garlic Alleviates the Injurious Impact of Cyclosporine-A in Male Rats through Modulation of Fibrogenic and Steroidogenic Genes.Animals : an open access journal from MDPI · 2020Article
- Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway.Molecules (Basel, Switzerland) · 2019Article
- Natural products in regulation of male fertility.The Indian journal of medical research · 2018Review
- Testicular toxicity and sperm quality following copper exposure in Wistar albino rats: ameliorative potentials of L-carnitine.Environmental science and pollution research international · 2018Article
- The potentiality of medicinal plants as the source of new contraceptive principles in males.North American journal of medical sciences · 2011Article
- Effects of plants and plant products on the testis.Asian journal of andrology · 2010Review
- Dynamic changes in the expression of apoptosis-related genes in differentiating gonocytes and in seminomas.Asian journal of andrologyArticle
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5 authors.
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Abstract
backgroundGarlic or Allium sativum (As) shows therapeutic effects such as reduction of blood pressure or hypercholesterolemia but side-effects on reproductive functions remain poorly investigated. Because of garlic's chemical complexity, the processing methods and yield in preparations differ in efficacy and safety. In this context, we clarify the mechanisms of action of crushed crude garlic on testicular markers.
methodsDuring one month of treatment, 24 male rats were fed 5%, 10% and 15% crude garlic.
resultsWe showed that crude garlic-feeding induced apoptosis in testicular germ cells (spermatocytes and spermatids). This cell death process was characterized by increased levels of active CASP3 but not CASP6. Expression of the caspase inhibitors BIRC3 and BIRC2 was increased at all doses of As while expression of XIAP and BIRC5 was unchanged. Moreover, expression of the IAP inhibitor DIABLO was increased at doses 10% and 15% of As. The germ cell death process induced by As might be related to a decrease in testosterone production because of the reduced expression of steroidogenic enzymes (Star, Cyp11a, Hsd3b5 and Hsd17b). Evaluation of Sertoli markers showed that TUBB3 and GSTA2 expression was unchanged. In contrast, AMH, RHOX5 and CDKN1B expression was decreased while GATA4 expression was increased.
conclusionIn summary, we showed that feeding with crude garlic inhibited Leydig steroidogenic enzyme expression and Sertoli cell markers. These alterations might induce apoptosis in testicular germ cells.
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