ArticleBritish journal of clinical pharmacology2009
Electrocardiogram changes and arrhythmias in venlafaxine overdose.
Article in British journal of clinical pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 66 citations in OpenAlex.
- The Effect of Venlafaxine on Electrocardiogram Intervals During Treatment for Depression in Older Adults.Journal of clinical psychopharmacologyTrial
- Therapeutic drug monitoring-guided management of venlafaxine overdose in an adolescent: a case report.Journal of analytical toxicology · 2026Article
- The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine.Cureus · 2022Review
- Article
- Venlafaxine overdose treated with extracorporeal life support.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Article
- Article
- Restarting antidepressant and antipsychotic medication after intentional overdoses: need for evidence-based guidance.Therapeutic advances in psychopharmacology · 2019Review
- Association Between Depression, Anxiety, and Antidepressant Use With T-Wave Amplitude and QT-Interval.Frontiers in neuroscience · 2018Article
- Antidepressants and the risk of arrhythmia in elderly affected by a previous cardiovascular disease: a real-life investigation from Italy.European journal of clinical pharmacology · 2018Article
- Lipid therapy and plasmapheresis in tricyclic poisoning.Proceedings (Baylor University. Medical Center) · 2016Article
- Impact of Age and Sex on QT Prolongation in Patients Receiving Psychotropics.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2015Review
- QTc interval prolongation and torsade de pointes associated with second-generation antipsychotics and antidepressants: a comprehensive review.CNS drugs · 2014Review
- Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice.British journal of clinical pharmacology · 2013Review
- A review of the suitability of duloxetine and venlafaxine for use in patients with depression in primary care with a focus on cardiovascular safety, suicide and mortality due to antidepressant overdose.Therapeutic advances in psychopharmacology · 2013Article
- The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose.British journal of clinical pharmacology · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias following venlafaxine overdose.
methodsThe study included 369 venlafaxine overdoses in 273 patients presenting to a toxicology unit where an ECG was available. Demographic information, details of ingestion, haemodynamic effects [heart rate and blood pressure (BP)] and complications (arrhythmias and conduction defects) were obtained. ECG parameters (QT, QRS) were measured manually and analysed by visual inspection, including plotting QT-HR pairs on a QT nomogram.
resultsThe median ingested dose was 1500 mg [interquartile range (IQR) 600-3000 mg; range 75-13 500 mg). Tachycardia occurred in 54% and mild hypertension (systolic BP >140 mmHg) in 40%. Severe hypertension (systolic BP >180 mmHg) and hypotension (systolic BP <90 mmHg) occurred in 3% and 5%, respectively. No arrhythmias occurred based on continuous telemetry, and conduction defects were found in only seven of 369 admissions; five of these conduction defects were pre-existing abnormalities. In 22 admissions [6%, 95% confidence interval (CI) 4-10] there was an abnormal QT-HR pair, with larger doses being more likely to be associated with an abnormal QT. The median maximum QRS width was 85 ms (IQR 80-90 ms; range 70-145 ms) and the QRS was greater than 120 ms in only 24 admissions (7%, 95% CI 4-10).
conclusionsVenlafaxine overdose causes only minor abnormalities in the QT and QRS intervals, unlikely to be associated with major arrhythmias, except possibly with large doses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.