ReviewTissue engineering. Part B, Reviews2009
Micro- and nanoscale control of the cardiac stem cell niche for tissue fabrication.
Review in Tissue engineering. Part B, Reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 86 citations in OpenAlex.
- Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips.Cell death & disease · 2026Article
- Nanotopographical Features of Polymeric Nanocomposite Scaffolds for Tissue Engineering and Regenerative Medicine: A Review.Biomimetics (Basel, Switzerland) · 2025Review
- Bio-printing of aligned GelMa-based cell-laden structure for muscle tissue regeneration.Bioactive materials · 2022Article
- Bioengineering approaches to mature induced pluripotent stem cell-derived atrial cardiomyocytes to model atrial fibrillation.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Gelatin Methacryloyl-Riboflavin (GelMA-RF) Hydrogels for Bone Regeneration.International journal of molecular sciences · 2021Article
- Aging: A cell source limiting factor in tissue engineering.World journal of stem cells · 2019Review
- Gelatin Methacrylate (GelMA)-Based Hydrogels for Cell Transplantation: an Effective Strategy for Tissue Engineering.Stem cell reviews and reports · 2019Review
- 3D bioprinted functional and contractile cardiac tissue constructs.Acta biomaterialia · 2018Article
- Article
- Cardiac Progenitor Cells and the Interplay with Their Microenvironment.Stem cells international · 2017Review
- Comparison of random and aligned PCL nanofibrous electrospun scaffolds on cardiomyocyte differentiation of human adipose-derived stem cells.Iranian journal of basic medical sciences · 2014Article
- Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs.Biomaterials · 2014Article
- Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications.Journal of tissue engineering and regenerative medicine · 2014Review
- Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System.Advanced functional materials · 2013Article
- Deciphering the combinatorial roles of geometric, mechanical, and adhesion cues in regulation of cell spreading.PloS one · 2013Article
- Microfabricated biomaterials for engineering 3D tissues.Advanced materials (Deerfield Beach, Fla.) · 2012Review
- Synthesis and characterization of tunable poly(ethylene glycol): gelatin methacrylate composite hydrogels.Tissue engineering. Part A · 2011Article
- Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels.Acta biomaterialia · 2011Article
- A cell-based biosensor for real-time detection of cardiotoxicity using lensfree imaging.Lab on a chip · 2011Article
- Cell-laden microengineered pullulan methacrylate hydrogels promote cell proliferation and 3D cluster formation.Soft matter · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Advances in stem cell (SC) biology have greatly enhanced our understanding of SC self-renewal and differentiation. Both embryonic and adult SCs can be differentiated into a great variety of tissue cell types, including cardiac myocytes. In vivo studies and clinical trials, however, have demonstrated major limitations in reconstituting the myocardium in failing hearts. These limitations include precise control of SC proliferation, survival and phenotype both prior and subsequent to transplantation and avoidance of serious adverse effects such as tumorigenesis and arrhythmias. Micro- and nanoscale techniques to recreate SC niches, the natural environment for the maintenance and regulation of SCs, have enabled the elucidation of novel SC behaviors and offer great promise in the fabrication of cardiac tissue constructs. The ability to precisely manipulate the interface between biopolymeric scaffolds and SCs at in vivo scale resolutions is unique to micro- and nanoscale approaches and may help overcome limitations of conventional biological scaffolds and methods for cell delivery. We now know that micro- and nanoscale manipulation of scaffold composition, mechanical properties, and three-dimensional architecture have profound influences on SC fate and will likely prove important in developing the next generation of "transplantable SC niches" for regeneration of heart and other tissues. In this review, we examine two key aspects of micro- and nanofabricated SC-based cardiac tissue constructs: the role of scaffold composition and the role of scaffold architecture and detail how recent work in these areas brings us closer to clinical solutions for cardiovascular regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.