ArticleJournal of neural transmission (Vienna, Austria : 1996)2009
Clustering and spatial correlations of the neuronal cytoplasmic inclusions, astrocytic plaques and ballooned neurons in corticobasal degeneration.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Signature laminar distributions of pathology in frontotemporal lobar degeneration.Acta neuropathologica · 2022Article
- Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease.Neurology · 2017Article
- Clustering of tau-immunoreactive pathology in chronic traumatic encephalopathy.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Different molecular pathologies result in similar spatial patterns of cellular inclusions in neurodegenerative disease: a comparative study of eight disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2012Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
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Abstract
This study tested three hypotheses: (1) that there is clustering of the neuronal cytoplasmic inclusions (NCI), astrocytic plaques (AP) and ballooned neurons (BN) in corticobasal degeneration (CBD), (2) that the clusters of NCI and BN are not spatially correlated, and (3) that the lesions are correlated with disease 'stage'. In 50% of the regions, clusters of lesions were 400-800 mum in diameter and regularly distributed parallel to the tissue boundary. Clusters of NCI and BN were larger in laminae II/III and V/VI, respectively. In a third of regions, the clusters of BN and NCI were negatively spatially correlated. Cluster size of the BN in the parahippocampal gyrus (PHG) was positively correlated with disease 'stage'. The data suggest the following: (1) degeneration of the cortico-cortical pathways in CBD, (2) clusters of NCI and BN may affect different anatomical pathways and (3) BN may develop after the NCI in the PHG.
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Registered trials
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