ArticleJournal of cancer research and clinical oncology2009
Prognostic significance of a pretreatment hematologic profile in patients with head and neck cancer.
Article in Journal of cancer research and clinical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta-analysis, and meta-regression.Cancer medicine · 2021Pooled it
- Precision immunotherapy for head and neck cancer: therapeutic combinations, biomarker strategies, and translational challenges.Molecular cancer · 2026Review
- Immune cell changes following chemotherapy in advanced pancreatic cancer with variations based on gender.Scientific reports · 2025Article
- 1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression.Frontiers in pharmacology · 2025Article
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- Phenotypic and functional heterogeneity of monocytes in health and cancer in the era of high dimensional technologies.Blood reviews · 2023Review
- Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study.International journal of clinical oncology · 2022Article
- Myeloproliferative Neoplasms with Monocytosis.Current hematologic malignancy reports · 2022Review
- Prognostic Value of Pretreatment Lymphocyte-to-Monocyte Ratio and Development of a Nomogram in Breast Cancer Patients.Frontiers in oncology · 2021Article
- Pretreatment peripheral neutrophils, lymphocytes and monocytes predict long-term survival in hepatocellular carcinoma.BMC cancer · 2020Article
- Peripheral blood monocyte counts are elevated in the pre-diagnostic phase of pancreatic cancer: A population based study.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2019Article
- Leukocytosis, prognosis biomarker in locally advanced head and neck cancer patients after chemoradiotherapy.Clinical and translational radiation oncology · 2018Article
- Cytokine Measurements for Diagnosing and Characterizing Leukemoid Reactions and Immunohistochemical Validation of a Granulocyte Colony-Stimulating Factor and CXCL8-Producing Renal Cell Carcinoma.Biomarker insights · 2018Article
- Article
- Prognostic value of pretherapy platelet elevation in oropharyngeal cancer patients treated with chemoradiation.International journal of cancer · 2016Article
- Preoperative mean corpuscular hemoglobin affecting long-term outcomes of hepatectomized patients with hepatocellular carcinoma.Molecular and clinical oncology · 2016Article
- Article
- Pretreatment platelet count improves the prognostic performance of the TNM staging system and aids in planning therapeutic regimens for nasopharyngeal carcinoma: a single-institutional study of 2,626 patients.Chinese journal of cancer · 2015Article
- Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2015Review
- An association between preoperative anemia and poor prognostic factors and decreased survival in early stage cervical cancer patients.Obstetrics & gynecology science · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this retrospective study was to test whether the pretreatment hematologic profile can predict the prognosis of patients with head and neck cancer.
methodsMedical records from 278 patients with head and neck cancer were reviewed, and 270 cases were evaluable. Clinical data including age, gender, stage, pretreatment hematologic profile (including white blood cell, platelet, and differential counts, and hemoglobin level) were recorded. Statistical analyses were performed to determine the prognostic effect of these hematologic indicators, as well as clinical variables. The association between the hematologic indicators and clinical factors was also analyzed.
resultsPretreatment monocytes >1,000 cells/microl (P = 0.028), hemoglobin <11.0 g/dl (P = 0.022), and platelet count >400 x 10(3) cells/microl (P = 0.017) were identified as independent prognostic factors in addition to the nodal status and metastasis. A significant correlation between T-stage/monocyte or platelet count and metastasis/platelet count were shown. Monocytosis, anemia, and thrombocytosis were demonstrated to have a cumulative effect on the prognosis of head and neck cancer patients (normal vs. abnormality in one lineage, P = 0.001; abnormality in one vs. more than one lineage, P = 0.005).
conclusionsA pretreatment hematologic profile can be considered as a useful prognostic marker in patients with head and neck cancer.
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