ArticleMediators of inflammation2009
The levels of tumor necrosis factor-alpha and interleukin-6 in patients with isolated coronary artery ectasia.
Article in Mediators of inflammation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Unravelling the Link between Inflammatory Biomarkers and Coronary Artery Ectasia Severity: A Systematic Review and Meta-Analysis.Cardiology · 2026Pooled it
- Regulation of mitochondrial autophagy by lncRNA MALAT1 in sepsis-induced myocardial injury.European journal of medical research · 2024Article
- Different Oxidative Stress and Inflammation Patterns of Diseased Left Anterior Descending Coronary Artery versus Internal Thoracic Artery.Antioxidants (Basel, Switzerland) · 2024Article
- Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia.Biomolecules · 2023Article
- Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Increased serum resistin levels associated with isolated coronary artery ectasia.Archives of medical sciences. Atherosclerotic diseases · 2022Article
- Association of systemic immune-inflammation index (SII) with presence of isolated coronary artery ectasia.Archives of medical sciences. Atherosclerotic diseases · 2021Article
- Could neutrophil/lymphocyte ratio be an indicator of coronary artery disease, coronary artery ectasia and coronary slow flow?The Journal of international medical research · 2016Observational
- Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells.The Journal of nutrition · 2016Article
- Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease.Balkan medical journal · 2015Article
- Predictive value of neutrophil to lymphocyte ratio for the presence of coronary artery ectasia in patients with aortic aneurysms.International journal of cardiology. Heart & vessels · 2014Article
- The Presence of Fragmented QRS on 12-Lead Electrocardiography in Patients with Coronary Artery Ectasia.Korean circulation journal · 2014Article
- Article
- Further increase in the expression of activation markers on monocyte-derived dendritic cells in coronary artery disease patients with ectasia compared to patients with coronary artery disease alone.Mediators of inflammation · 2010Article
- A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia.Cardiovascular journal of AfricaArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimCoronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-alpha and IL-6 in CAE patients.
methodsPlasma concentrations of TNF-alpha and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2 +/- 12 years), and results were compared with age and sex-matched controls (n = 32) without coronary artery ectasia. TNF-alpha and IL-6 concentrations in blood were assessed by enzyme-linked immunosorbent assay (ELISA).
resultsBaseline characteristics of the two groups were similar. TNF-alpha and IL-6 levels were significantly higher in CAE group than controls (15.6 +/- 11.2 pg/mL versus 7.8 +/- 3.7 pg/mL, P < .001, and 17.2 +/- 12.6 versus 7.6 +/- 2.1 P < .0001, resp.).
conclusionCAE patients showed increases in TNF-alpha and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflammatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-alpha and IL-6 levels.
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