ArticleEuropean journal of clinical nutrition2009
Folate intake and the risk of colorectal cancer in a Korean population.
Article in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis.World journal of gastroenterology · 2019Pooled it
- Lower Relative Contribution of Positive Family History to Colorectal Cancer Risk with Increasing Age: A Systematic Review and Meta-Analysis of 9.28 Million Individuals.The American journal of gastroenterology · 2018Pooled it
- Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea.BMC cancer · 2014Pooled it
- Inverse relationship between moderate alcohol intake and rectal cancer: analysis of the North Carolina Colon Cancer Study.Diseases of the colon and rectum · 2011Trial
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- The Roles ofNutrients · 2022Article
- Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning.International journal of molecular sciences · 2020Article
- Identification of major dietary patterns in Korean adults and their association with cancer risk in the Cancer Screening Examination Cohort.European journal of clinical nutrition · 2017Article
- Dietary patterns and colorectal cancer risk in a Korean population: A case-control study.Medicine · 2016Observational
- Alcohol Drinking, Cigarette Smoking and Risk of Colorectal Cancer in the Korean Multi-center Cancer Cohort.Journal of cancer prevention · 2015Article
- Associations of colorectal cancer incidence with nutrient and food group intakes in korean adults: a case-control study.Clinical nutrition research · 2015Article
- Isoflavone and Soyfood Intake and Colorectal Cancer Risk: A Case-Control Study in Korea.PloS one · 2015Article
- Contemporary issues surrounding folic Acid fortification initiatives.Preventive nutrition and food science · 2014Review
- Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea.BMC cancer · 2014Article
- Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.The Journal of nutrition · 2014Article
- Article
- Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.Cancer research · 2011Article
- Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.Clinical and experimental gastroenterology · 2011Article
- The conundrum of folate and colorectal cancer (CRC) risk.European journal of clinical nutrition · 2010Article
- Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFolate, a water-soluble B vitamin and one of the major micronutrients in vegetables, is known as an essential factor for the de novo biosynthesis of purines and thymidylate, and it plays an important role in DNA synthesis and replication. Thus, folate deficiency results in ineffective DNA synthesis, and has been shown to induce the initiation and progression of colorectal cancer (CRC). Recently, the incidence of CRC in Korea has increased markedly in both men and women; this trend may be related to the adoption of a more 'westernized' lifestyle, including dietary habits.
objectiveA hospital-based case-control study was conducted to examine the relationship between folate intake and the risk of CRC within a Korean population.
methodsA total of 596 cases and 509 controls, aged 30-79 years, were recruited from two university hospitals. Site- and sex-specific odds ratios (ORs) were estimated using logistic regression models.
resultsCases were more frequently found to have a family history of CRC among first-degree relatives, to consume more alcohol, to be more likely current smokers and less likely to participate in vigorous physical activity than the controls. In the overall data for men and women combined, multivariate ORs (95% confidence interval (CI), P for trend) comparing the highest vs the lowest quartile of dietary folate intake were: 0.47 (0.32-0.69, <0.001) for CRC, 0.42 (0.26-0.69, <0.001) for colon cancer and 0.48 (0.28-0.81, 0.007) for rectal cancer. An inverse association was also found in women with dietary folate intake: 0.36 (0.20-0.64, <0.001) for CRC, 0.34 (0.16-0.70, 0.001) for colon cancer and 0.30 (0.12-0.74, 0.026) for rectal cancer, but not in men. In addition, the total folate intake of women was strongly associated with a reduced risk of rectal cancer (OR, 0.38; 95% CI, 0.17-0.88; P for trend=0.04).
conclusionWe found a statistically significant relationship between higher dietary folate intake and reduced risk of CRC, colon cancer and rectal cancer in women. A significant association is indicated between higher total folate intake and reduced risk of rectal cancer in women.
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