Trial reportEuropean journal of clinical nutrition2009
Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects.
Trial report in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02549534 (Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Who cites it
16 citing papers in PubMed.
- Acute dose-response effect of coffee-derived chlorogenic acids on the human vasculature in healthy volunteers: a randomized controlled trial.The American journal of clinical nutrition · 2021Trial
- The gut microbiome drives inter- and intra-individual differences in metabolism of bioactive small molecules.Scientific reports · 2020Trial
- Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension.European journal of nutrition · 2019Trial
- Acute effects of coffee on QT interval in healthy subjects.Nutrition journal · 2011Trial
- Acute effects of coffee on endothelial function in healthy subjects.European journal of clinical nutrition · 2010Trial
- Article
- Role of Polyphenols and Carotenoids in Endothelial Dysfunction: An Overview from Classic to Innovative Biomarkers.Oxidative medicine and cellular longevity · 2020Review
- Coffee and Endothelial Function: A Coffee Paradox?Nutrients · 2019Review
- The role of polyphenols in modern nutrition.Nutrition bulletin · 2017Review
- Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study.European journal of clinical nutrition · 2016Article
- Influence of different doses of coffee on post-exercise blood pressure response.American journal of cardiovascular disease · 2016Article
- Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study.European journal of nutrition · 2015Article
- Habitual consumption of coffee and green tea in relation to serum adipokines: a cross-sectional study.European journal of nutrition · 2015Article
- Factors associated with metabolic syndrome in a mediterranean population: role of caffeinated beverages.Journal of epidemiology · 2014Article
- Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.Antioxidants & redox signaling · 2013Review
- Coffee and endothelial function: a battle between caffeine and antioxidants?European journal of clinical nutrition · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesCoffee is known to contain antioxidant substances whose effects may be blunted because of caffeine that may unfavorably affect the cardiovascular system. This study was designed to investigate the acute dose-dependent effects of decaffeinated coffee (DC) on endothelial function measured by the brachial artery flow-mediated dilation (FMD). SUBJECTS/
methodsA total of 15 (8 men and 7 women) healthy nonobese subjects underwent a single-blind, crossover study. Subjects ingested one and two cups of decaffeinated Italian espresso coffee in random order at 5- to 7-day intervals.
resultsIn the hour following the ingestion of two cups of DC, FMD increased (mean+/-s.e.m.): 0 min, 7.4+/-0.7%; 30 min, 8.0+/-0.6%; 60 min, 10.8+/-0.8%; P<0.001) as compared to consumption of one cup of DC (0 min, 6.9+/-0.7%; 30 min, 8.4+/-1.2%; 60 min, 8.5+/-1.1%; 3 x 2 repeated-measures analysis of variance: P=0.037 for time x treatment effect). Blood pressure did not differ between groups, and basal heart rate was lower in the two-cup group at baseline and 60 min.
conclusionsThe present study demonstrated a significant acute favorable dose-dependent effect of decaffeinated espresso coffee on endothelial function. Further studies are needed to investigate the effects of chronic use of DC especially with respect to caffeinated coffee and in subjects with cardiovascular diseases.
Indexed as
Identifiers
19550428What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.