Evidence map›Paper›PMID 19550320›Full record

ReviewCurrent opinion in hematology2009

The platelet proteome.

Lisa Senzel, Dmitri V Gnatenko, Wadie F Bahou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lisa SenzelDepartment of Pathology, University Hospital, State University of New York, Stony Brook, NY 11794-7300, USA. lsenzel@notes.cc.sunysb.edu
Dmitri V Gnatenko
Wadie F Bahou
State University of New York · USStony Brook University · US

Funding

Platelet Systems Biology in Health and DiseaseR01HL119096 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAHOU, WADIE F · 2015 to 2019
$3.5M
Genetic dissection of the platelet thrombohemorrhagic phenotypeR01HL091939 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAHOU, WADIE F · 2009 to 2012
$1.6M
Molecular profiling of the platelet thrombohemorrhagicR21HL086376 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI BAHOU, WADIE F · 2006 to 2007
$416k
NHLBI NIH HHS HL086378NHLBI NIH HHS HL091939NHLBI NIH HHS R01 HL091939NHLBI NIH HHS R01 HL119096NHLBI NIH HHS R21 HL086376
6 · The paper itself

Abstract

purpose of reviewThe proteome is the pool of proteins expressed at a given time and circumstance. The word 'proteomics' summarizes several technologies for visualization, quantitation and identification of these proteins. Recent advances in these techniques are helping to elucidate platelet processes which are relevant to bleeding and clotting disorders, transfusion medicine and regulation of angiogenesis. RECENT

findingsOver 1100 platelet proteins have been identified using proteomic techniques. Various subproteomes have been characterized, including platelet releasates (the 'secretome'), alpha and dense granules, membrane and cytoskeletal proteins, platelet-derived microparticles, and the platelet 'phosphoproteome'. Proteomic data about platelets have become increasingly available in integrated databases. SUMMARY: Proteomic experiments in resting and activated platelets have identified novel signaling pathways and secreted proteins which may represent therapeutic targets, as well as potential cancer biomarkers.

Indexed as

Blood PlateletsCell-Derived MicroparticlesHumansPlatelet ActivationProteomeProteomicsSignal TransductionProteome

Identifiers

PMID19550320
PMCPMC2883290
OpenAlexW2130679926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.