ArticleAIDS (London, England)2009
Longitudinal changes in regional fat content in HIV-infected children and adolescents.
Article in AIDS (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy.Archives of disease in childhood · 2013Trial
- Association of Perinatal HIV Exposure and HIV Disease Severity With BP in Youth.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Health-Related Physical Fitness Evaluation in HIV-Diagnosed Children and Adolescents: A Scoping Review.International journal of environmental research and public health · 2024Article
- Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV.HIV medicine · 2024Article
- Cardiometabolic Complications in Youth With Perinatally Acquired HIV in the Era of Antiretroviral Therapy.Current HIV/AIDS reports · 2021Review
- Longitudinal Changes in Body Composition by Dual-energy Radiograph Absorptiometry Among Perinatally HIV-infected and HIV-uninfected Youth: Increased Risk of Adiposity Among HIV-infected Female Youth.The Pediatric infectious disease journal · 2018Article
- Anthropometry and body composition of vertically HIV-infected children and adolescents under therapy with and without protease inhibitors.Public health nutrition · 2015Article
- Pubertal development in HIV-infected African children on first-line antiretroviral therapy.AIDS (London, England) · 2015Observational
- Prevalence of lipodystrophy and metabolic abnormalities in HIV-infected African children after 3 years on first-line antiretroviral therapy.The Pediatric infectious disease journal · 2015Article
- HIV/AIDS and lipodystrophy: implications for clinical management in resource-limited settings.Journal of the International AIDS Society · 2015Review
- Cardiac effects in perinatally HIV-infected and HIV-exposed but uninfected children and adolescents: a view from the United States of America.Journal of the International AIDS Society · 2013Review
- Physical fitness in children infected with the human immunodeficiency virus: associations with highly active antiretroviral therapy.AIDS research and human retroviruses · 2013Article
- Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV-infected children.HIV medicine · 2012Article
- Body fat distribution in perinatally HIV-infected and HIV-exposed but uninfected children in the era of highly active antiretroviral therapy: outcomes from the Pediatric HIV/AIDS Cohort Study.The American journal of clinical nutrition · 2011Article
- Severe malnutrition and metabolic complications of HIV-infected children in the antiretroviral era: clinical care and management in resource-limited settings.The American journal of clinical nutrition · 2011Review
- Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1.Journal of acquired immune deficiency syndromes (1999) · 2010Article
- Are traditional body fat equations and anthropometry valid to estimate body fat in children and adolescents living with HIV?The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
8 authors.
Funding
Abstract
backgroundAlterations in regional fat are often reported in HIV infection. Prior studies have not distinguished between normal changes in regional fat related to sexual maturation and those due to HIV. The study aim was to compare changes in regional fat distribution in HIV-infected (HIV+) and healthy (HIV-) children and adolescents living in the United States.
methodsSerial dual energy X-ray absorptiometry was performed at baseline and two annual follow-up visits in 64 HIV+ and 147 HIV--participants aged 6-16 years. Total, leg, arm, and trunk fat masses (kg) and regional fat distribution as the percentage of total body fat (%) were compared.
resultsHIV+ and HIV--participants did not differ in total fat mass, but the HIV+ group had significantly lower leg and greater arm fat and trunk fat percentage at all time points. Over time, decreases in leg fat percentage and increases in arm fat percentage were more marked among the HIV+ group. Differences between HIV+ and HIV--groups in arm and leg fat percentage remained significant when age, sex, race, height, and pubertal stage were accounted for by mixed effect modeling. Apart from prior treatment with stavudine, no differences in fat distribution were observed according to treatment or degree of immunodeficiency or viremia.
conclusionAlthough no single pattern of change in regional fat distribution was uniquely associated with HIV, perinatally HIV-infected youth manifest significantly decreased leg fat and increased arm and trunk fat. These differences increase over time and may contribute to cardiovascular disease risk.
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