ArticleThe Journal of nutrition2009
Associations of gestational exposure to famine with energy balance and macronutrient density of the diet at age 58 years differ according to the reference population used.
Article in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Pooled it
- Childhood obesity: prevention and strategies of intervention. A systematic review of school-based interventions in primary schools.Journal of endocrinological investigation · 2014Pooled it
- Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children.Pediatric research · 2023Article
- Thrifty-Eating Behavior Phenotype at the Food Court - Programming Goes Beyond Food Preferences.Frontiers in endocrinology · 2022Article
- Article
- Effects of early-life exposure to Western diet and voluntary exercise on adult activity levels, exercise physiology, and associated traits in selectively bred High Runner mice.Physiology & behavior · 2021Article
- Impact of Early Life or Intrauterine Factors and Socio-Economic Interaction on Diabetes - An Evidence on Thrifty Hypothesis.Journal of lifestyle medicine · 2019Review
- Feeding circuit development and early-life influences on future feeding behaviour.Nature reviews. Neuroscience · 2018Review
- DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.Science advances · 2018Article
- Maternal exposure to Western diet affects adult body composition and voluntary wheel running in a genotype-specific manner in mice.Physiology & behavior · 2017Article
- Perinatal high methyl donor alters gene expression in IGF system in male offspring without altering DNA methylation.Future science OA · 2017Article
- Dietary intake in young adults born small or appropriate for gestational age: data from the Haguenau cohort.BMJ open · 2016Article
- The association of birth weight and postnatal growth with energy intake and eating behavior at 5 years of age - a birth cohort study.The international journal of behavioral nutrition and physical activity · 2016Article
- Developmental contributions to macronutrient selection: a randomized controlled trial in adult survivors of malnutrition.Evolution, medicine, and public health · 2016Article
- Review
- Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.International journal of epidemiology · 2015Article
- Comparison of the China growth charts with the WHO growth standards in assessing malnutrition of children.BMJ open · 2015Article
- Famines in the last 100 years: implications for diabetes.Current diabetes reports · 2014Review
- Novel "thrifty" models of increased eating behaviour.Current psychiatry reports · 2013Review
- Study protocol: the relation of birth weight and infant growth trajectories with physical fitness, physical activity and sedentary behavior at 8-9 years of age - the ABCD study.BMC pediatrics · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Individuals exposed to the Dutch Famine of 1944-45 during gestation have increased adiposity, which might be due to changes in energy intake, physical activity, or metabolic efficiency. We studied 357 persons born between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 298 persons born in the same 3 institutions during 1943 or 1947 (time controls), and 311 same-sex sibling controls. We obtained food frequency and physical activity data by questionnaire between 2003 and 2005 (mean age 58 y). We defined gestational exposure as exposure to a ration of <3762 kJ/d (<900 kcal/d) for at least 10 wk. For the whole study population, energy intake was 9225 +/- 2650 kJ/d and physical activity was 7380 +/- 4331 metabolic equivalents (MET).min/wk. Compared with time controls, gestational famine exposure was associated with 113 kJ/d (95% CI, -272, 502) higher energy intake, 0.01 percentage point (95% CI, -0.88, 0.89) higher fat density, 688 MET.min/wk (95% CI, -1398, 23) lower physical activity, and 63 kJ/d (95% CI, -130, 259) higher predicted energy expenditure (pEE). Compared with sibling controls, gestational famine exposure was associated with 4 kJ/d (95% CI, -702, 711) higher energy intake, 2.01 percentage points (95% CI, 0.38, 3.63) higher fat density, 97 MET.min/wk) (95% CI, -1243, 1050) lower physical activity score, and 188 kJ/d (95% CI, -163, 539) higher pEE. Gender-specific associations (P < 0.05 for heterogeneity) emerged for protein density and pEE using time controls and for energy intake using sibling controls. Associations were weak, differed by choice of control, and may reflect sampling variability or methodological differences. Persistent small energy imbalances could explain the increased weight of famine-exposed individuals.
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