ArticleGastroenterology2009
Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse.
Article in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders.International journal of medical sciences · 2026Review
- P2X7 and P2YPurinergic signalling · 2025Article
- Electroacupuncture alleviates zymosan-induced colorectal hypersensitivity.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Electrophysiology as a Tool to Decipher the Network Mechanism of Visceral Pain in Functional Gastrointestinal Disorders.Diagnostics (Basel, Switzerland) · 2023Review
- An anesthesia protocol for robust and repeatable measurement of behavioral visceromotor responses to colorectal distension in mice.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Oral cancer induced TRPV1 sensitization is mediated by PARScientific reports · 2022Article
- Upregulation of P2X3 receptors in primary afferent pathways involves in colon-to-bladder cross-sensitization in rats.Frontiers in physiology · 2022Article
- Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19.Immunopharmacology and immunotoxicology · 2021Review
- Gene expression analysis in NSAID-induced rat small intestinal disease model with the intervention of berberine by the liquid chip technology.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Purinergic P2 Receptors: Novel Mediators of Mechanotransduction.Frontiers in pharmacology · 2021Review
- Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases.Frontiers in physiology · 2021Review
- Neuromechanism of acupuncture regulating gastrointestinal motility.World journal of gastroenterology · 2020Review
- Visceral pain from colon and rectum: the mechanotransduction and biomechanics.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Epithelial-Neuronal Communication in the Colon: Implications for Visceral Pain.Trends in neurosciences · 2020Review
- Inhibitory effect of estrogen receptor beta on P2X3 receptors during inflammation in rats.Purinergic signalling · 2017Article
- Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system.Purinergic signalling · 2016Article
- Optogenetic activation of mechanically insensitive afferents in mouse colorectum reveals chemosensitivity.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
BACKGROUND &
aimsIrritable bowel syndrome is characterized by altered sensory qualities, namely discomfort/pain and colorectal hypersensitivity. In mice, we examined the role of P2X(3) receptors in colon mechanosensitivity and intracolonic zymosan-produced hypersensitivity, a model of persistent colon hypersensitivity without colon inflammation.
methodsThe visceromotor response to colon distension (15-60 mm Hg) was determined before and after intracolonic saline or zymosan (30 mg/mL, 0.1 mL, daily for 3 days) treatment. Colon pathology and intracolonic adenosine triphosphate release was assessed in parallel experiments. To examine P2X(3) receptor contributions to colon mechanosensation and hypersensitivity, electrophysiologic experiments were performed using an in vitro colon-pelvic nerve preparation.
resultsVisceromotor responses to distension were significantly reduced in P2X(3)(+/-) and P2X(3)(-/-) mice relative to wild-type mice. Colon hypersensitivity produced by zymosan was virtually absent in P2X(3)(-/-) relative to wild-type or P2X(3)(+/-) mice. Intralumenal release of the endogenous P2X receptor ligand adenosine triphosphate did not differ between wild-type and P2X(3)(-/-) mice or change after intracolonic zymosan treatment. Responses of muscular and muscular-mucosal pelvic nerve afferents to mechanical stretch did not differ between P2X(3)(-/-) and wild-type mice. Both muscular and muscular-mucosal afferents in wild-type mice sensitized to application of an inflammatory soup, whereas only muscular-mucosal afferents did so in P2X(3)(-/-) mice.
conclusionsThese results suggest differential roles for peripheral and central P2X(3) receptors in colon mechanosensory transduction and hypersensitivity.
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