ArticleCritical care (London, England)2009
Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review.Critical care (London, England) · 2010Pooled it
- Hyponatremia and takotsubo syndrome: a review of pathogenetic and clinical implications.Heart failure reviews · 2024Review
- How I Do It: Endovascular Management of Acute Nonvariceal Gastrointestinal Bleeding.Seminars in interventional radiology · 2023Review
- Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications.Balkan medical journal · 2023Article
- Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis.Frontiers in immunology · 2022Review
- Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation.International journal of molecular sciences · 2021Review
- Distribution and relative expression of vasoactive receptors on arteries.Scientific reports · 2020Article
- Hyponatraemia aggravates cardiac susceptibility to ischaemia/reperfusion injury.International journal of experimental pathology · 2019Article
- Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways.Frontiers in neuroscience · 2019Review
- Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2018Article
- Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease.International journal of molecular sciences · 2018Review
- Prevention preferable to treatment: 3 case reports of patients experiencing right-sided heart failure after Ebstein anomaly correction.Medicine · 2017Article
- Arginine vasopressin receptor signaling and functional outcomes in heart failure.Cellular signalling · 2016Review
- Acute organ injury is associated with alterations in the cell-free plasma transcriptome.Intensive care medicine experimental · 2014Article
- β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling.Circulation · 2014Article
- Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia.The Journal of pediatrics · 2014Article
- Management of acute right ventricular failure in the intensive care unit.Annals of the American Thoracic Society · 2014Review
- The role of oxytocin in cardiovascular regulation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Review
- Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/β-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells.Molecular pharmacology · 2013Article
- Oroxylin a, but not vasopressin, ameliorates cardiac dysfunction of endotoxemic rats.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionArginine vasopressin is a vasoactive drug commonly used in distributive shock states including mixed shock with a cardiac component. However, the direct effect of arginine vasopressin on the function of the ischemia/reperfusion injured heart has not been clearly elucidated.
methodsWe measured left ventricular ejection fraction using trans-thoracic echocardiography in C57B6 mice, both in normal controls and following ischemia/reperfusion injury induced by a one hour ligation of the left anterior descending coronary artery. Mice were treated with one of normal saline, dobutamine (8.33 microg/kg/min), or arginine vasopressin (0.00057 Units/kg/min, equivalent to 0.04 Units/min in a 70 kg human) delivered by an intraperitoneal micro-osmotic pump. Arterial blood pressure was measured using a micromanometer catheter. In addition, mortality was recorded and cardiac tissues processed for RNA and protein.
resultsBaseline left ventricular ejection fraction was 65.6% (60 to 72). In normal control mice, there was no difference in left ventricular ejection fraction according to infusion group. Following ischemia/reperfusion injury, AVP treatment significantly reduced day 1 left ventricular ejection fraction 46.2% (34.4 to 52.0), both in comparison with baseline and day 1 saline treated controls 56.9% (42.4 to 60.2). There were no significant differences in preload (left ventricular end diastolic volume), afterload (blood pressure) or heart rate to account for the effect of AVP on left ventricular ejection fraction. The seven-day mortality rate was highest in the arginine vasopressin group. Following ischemia/reperfusion injury, we found no change in cardiac V1 Receptor expression but a 40% decrease in Oxytocin Receptor expression.
conclusionsArginine vasopressin infusion significantly depressed the myocardial function in an ischemia/reperfusion model and increased mortality in comparison with both saline and dobutamine treated animals. The use of vasopressin may be contraindicated in non-vasodilatory shock states associated with significant cardiac injury.
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