ArticleCancer science2009
Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway.
Article in Cancer science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
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- The Emerging Roles of ATP-Dependent Chromatin Remodeling Complexes in Pancreatic Cancer.Cancers · 2019Review
- ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway.International journal of oncology · 2019Article
- The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis.EMBO reports · 2019Review
- CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells' Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy.Oxidative medicine and cellular longevity · 2019Article
- Scinderin-knockdown inhibits proliferation and promotes apoptosis in human breast carcinoma cells.Oncology letters · 2018Article
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- siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.Translational medicine @ UniSa · 2017Article
- siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.Translational medicine @ UniSa · 2017Article
- Overexpression of MPC1 inhibits the proliferation, migration, invasion, and stem cell-like properties of gastric cancer cells.OncoTargets and therapy · 2017Article
- Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.Cancer letters · 2016Article
- MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.Scientific reports · 2016Article
- The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells.American journal of cancer research · 2016Article
- Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2015Review
- The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway.Journal of experimental & clinical cancer research : CR · 2015Article
- Aldehyde dehydrogenase 1A1 circumscribes high invasive glioma cells and predicts poor prognosis.American journal of cancer research · 2015Article
- MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer.Molecular cancer · 2014Article
- The significance of LRPPRC overexpression in gastric cancer.Medical oncology (Northwood, London, England) · 2014Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the expression and role of the 58-kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacent non-tumor tissues (92.5 vs 36.3%, P < 0.01). The average staining score in adjacent non-tumor tissues was significantly lower than in CRC tissues (2.05 +/- 1.13 vs 5.23 +/- 1.38, P < 0.01). Moreover, MSP58 mRNA and protein appeared to be upregulated in six fresh CRC samples compared to their adjacent non-cancerous tissues. MSP58 expression was also detected in the human CRC-derived cell lines LoVo, CoLo205, HCT116, HT-29, SW620, and SW480. Downregulation of MSP58 inhibited in vitro growth and attenuated tumor growth in animal models by induction of cell cycle arrest, and was associated with reduced levels of cyclin D1, cyclin-dependent kinase 4, phosphorylation-Rb (p-Rb), p21, and Retino blastoma (Rb) proteins. These results indicated that MSP58 might play an important role in the carcinogenesis of CRC via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway.
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