ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2009
Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Extracellular Pgk1 or Its Derived Short Peptide Interacted with Membrane-Associated Enolase 2 Receptor: A Potential Therapy for ALS Motor Neuron Degeneration.Biomolecules · 2026Review
- The Implication of Reticulons (RTNs) in Neurodegenerative Diseases: From Molecular Mechanisms to Potential Diagnostic and Therapeutic Approaches.International journal of molecular sciences · 2021Review
- Article
- Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis.Aging and disease · 2019Article
- Synaptic Failure: Focus in an Integrative View of ALS.Brain plasticity (Amsterdam, Netherlands) · 2016Review
- The role of reticulons in neurodegenerative diseases.Neuromolecular medicine · 2014Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Improved biomarkers would facilitate the diagnosis and treatment of amyotrophic lateral sclerosis (ALS). Muscle content of the neuritic outgrowth inhibitor Nogo-A is increased in patients with ALS and other denervating conditions. Seeking a less invasive diagnostic method, we sought to determine whether or not Nogo increases in the serum of ALS patients. We developed a dissociation-enhanced lanthanide fluorescent immunoassay (DELFIA) protocol to screen serum samples from 172 ALS patients and 172 healthy controls for Nogo-A immunoreactivity. Unexpectedly, there was a trend toward decreased levels of serum Nogo-A in ALS. Mean serum Nogo-A level in ALS patients was 0.71 nM (95% confidence interval (CI) 0.42-1.00), as opposed to 1.15 nM (95% CI 0.72-1.59) in healthy controls. A significantly larger percentage of healthy control sera (11.0% vs 4.7%) displayed markedly elevated levels of Nogo-A. Additional study is required to determine the factors that lead to elevated Nogo-A levels in a subset of both ALS patients and healthy controls.
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Registered trials
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