ArticleEuropean journal of pediatrics2010
Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.
Article in European journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- Trial
- Evaluation of hepatic infantile hemangiomas: the potential of contrast-enhanced ultrasound.Frontiers in cardiovascular medicine · 2026Article
- Consumptive hypothyroidism complicating infantile hepatic hemangioma successfully treated with propranolol: a case report and literature review.Italian journal of pediatrics · 2025Review
- Consumptive Hypothyroidism due to Hepatic Hemangiomas: A Case Series and Review of the Literature.JPGN reports · 2022Review
- Hepatic Hemangioendothelioma: A Rare Cause of Congenital Hypothyroidism.Indian journal of pediatrics · 2019Article
- Resolution of Consumptive Hypothyroidism Secondary to Infantile Hepatic Hemangiomatosis with a Combination of Propranolol and LevothyroxineJournal of clinical research in pediatric endocrinology · 2018Article
- Plasma 3,3',5-Triiodo-L-thyronine [T3] level mirrors changes in tumor markers in two cases of metastatic cancer of the breast and pancreas treated with exogenous L-T3.Cancer biomarkers : section A of Disease markers · 2018Article
- Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.European thyroid journal · 2017Article
- Thyroid disease in children: part 1: State-of-the-art imaging in pediatric hypothyroidism.Pediatric radiology · 2013Review
- Type 3 deiodinase and consumptive hypothyroidism: a common mechanism for a rare disease.Frontiers in endocrinology · 2013Review
- The Italian screening program for primary congenital hypothyroidism: actions to improve screening, diagnosis, follow-up, and surveillance.Journal of endocrinological investigation · 2013Review
- Iodothyronine deiodinases and cancer.Journal of endocrinological investigation · 2011Review
- Autoimmune thyroid diseases in children.Journal of thyroid research · 2010Article
- The syndrome of inherited partial SBP2 deficiency in humans.Antioxidants & redox signaling · 2010Review
- Hypothyroidism due to hepatic hemangioendothelioma: a case report.Journal of clinical research in pediatric endocrinology · 2010Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfantile hepatic hemangioma with consumptive hypothyroidism is a rare condition. CASE REPORT: A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected. The expression and activity of type 3 iodothyronine deiodinase (D3) were elevated in the resected tumor tissue compared with placenta. DISCUSSION: Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy. The etiology of elevated D3 activity is also discussed.
conclusionIt is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients.
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