Evidence map›Paper›PMID 19547751›Full record

ReviewDeutsches Arzteblatt international2009

The differential diagnosis of food intolerance.

Yurdagül Zopf, Hanns-Wolf Baenkler, Andrea Silbermann, Eckhart G Hahn, Martin Raithel

Registry-linked trialAbstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05482997 (Athlete Whey Protein Sensitivity), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05482997 nacompletednot on this mapstarted 2023, after this paper: background citation

Athlete Whey Protein Sensitivity: Prevalence and Performance

TypeinterventionalSponsorUniversity of the Incarnate WordRan2023 to 2023Enrolled36ConditionsFood IntoleranceArmsWhey Protein Concentrate, Pea Protein Isolate, Rice Protein Concentrate, Hemp Protein
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Clinical Outcomes and Food Triggers Following Low Food Chemical Diet Implementation: A Retrospective Audit of Dietetic Practice.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Molecular Mechanisms of Eosinophilic Esophagitis.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Food allergy: separating the science from the mythology.Nature reviews. Gastroenterology & hepatology · 2010
    Review
  17. Mopane worm allergy in a 36-year-old woman: a case report.Journal of medical case reports · 2010
    Article
  18. Correction required.Deutsches Arzteblatt international · 2010
    Article
  19. Bacteriological stool examinations.Deutsches Arzteblatt international · 2010
    Article
  20. Clinical relevance.Deutsches Arzteblatt international · 2010
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yurdagül ZopfMedizinische Klinik 1, Gastroenterologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. yurdaguel.zopf@uk-erlangen.de
Hanns-Wolf Baenkler
Andrea Silbermann
Eckhart G Hahn
Martin Raithel

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMore than 20% of the population in industrialized countries suffer from food intolerance or food allergy.

methodsSelective literature search for relevant publications in PubMed and the Cochrane Library combined with further data from the interdisciplinary database on chronic inflammatory and allergic diseases of the Erlangen University Hospital.

resultsThe majority of cases of food intolerance (15% to 20%) are due to non-immunological causes. These causes range from pseudoallergic reactions to enzymopathies, chronic infections, and psychosomatic reactions that are associated with food intolerance. The prevalence of true food allergy, i.e., immunologically mediated intolerance reactions, is only 2% to 5%.

conclusionsThe differential diagnosis of food intolerance is broad. Therefore, a structured diagnostic algorithm with input from multiple clinical disciplines should be applied. The treatment consists of eliminating the offending substance from the diet as well as medications and psychosomatic support, when indicated.

Indexed as

Diagnosis, DifferentialFood AnalysisFood HypersensitivityHumansImmunologic Testscritical appraisaldecision makingdiagnosisfood allergyFood intolerancehistamine intoleranceprovocative testingquality assurancestudy

Identifiers

PMID19547751
PMCPMC2695393

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.