ArticlePLoS biology2009
Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- The Vap33 signaling axis precisely coordinates the timing of motoneuron dendritogenesis in neural map development.Nature communications · 2025Article
- Formation of sensory maps: New tools reveal novel insights into neural development.Current opinion in neurobiology · 2025Review
- The Hunchback transcription factor determines interneuron molecular identity, morphology, and presynapse targeting in the Drosophila NB5-2 lineage.PLoS biology · 2025Article
- Molecular regulation of axon termination in mechanosensory neurons.Development (Cambridge, England) · 2024Review
- Protein O-mannosylation: one sugar, several pathways, many functions.Glycobiology · 2023Review
- A Drosophila glial cell atlas reveals a mismatch between transcriptional and morphological diversity.PLoS biology · 2023Article
- Nociception in fruit fly larvae.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Distinctive features of the central synaptic organization ofFrontiers in neural circuits · 2023Article
- A model for self-organization of sensorimotor function: the spinal monosynaptic loop.Journal of neurophysiology · 2022Article
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- The atypical cadherin flamingo determines the competence of neurons for activity-dependent fine-scale topography.Molecular brain · 2019Article
- Positional Strategies for Connection Specificity and Synaptic Organization in Spinal Sensory-Motor Circuits.Neuron · 2019Article
- Article
- The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting inDevelopment (Cambridge, England) · 2019Article
- Midline axon guidance in the Drosophila embryonic central nervous system.Seminars in cell & developmental biology · 2019Review
- Strategies for assembling columns and layers in the Drosophila visual system.Neural development · 2018Review
- Neural circuits driving larval locomotion in Drosophila.Neural development · 2018Review
- Diversity of Internal Sensory Neuron Axon Projection Patterns Is Controlled by the POU-Domain Protein Pdm3 inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
During the development of neural circuitry, neurons of different kinds establish specific synaptic connections by selecting appropriate targets from large numbers of alternatives. The range of alternative targets is reduced by well organised patterns of growth, termination, and branching that deliver the terminals of appropriate pre- and postsynaptic partners to restricted volumes of the developing nervous system. We use the axons of embryonic Drosophila sensory neurons as a model system in which to study the way in which growing neurons are guided to terminate in specific volumes of the developing nervous system. The mediolateral positions of sensory arbors are controlled by the response of Robo receptors to a Slit gradient. Here we make a genetic analysis of factors regulating position in the dorso-ventral axis. We find that dorso-ventral layers of neuropile contain different levels and combinations of Semaphorins. We demonstrate the existence of a central to dorsal and central to ventral gradient of Sema 2a, perpendicular to the Slit gradient. We show that a combination of Plexin A (Plex A) and Plexin B (Plex B) receptors specifies the ventral projection of sensory neurons by responding to high concentrations of Semaphorin 1a (Sema 1a) and Semaphorin 2a (Sema 2a). Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.