ArticleGenome research2009
Epigenetics of human T cells during the G0-->G1 transition.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Epigenomic signatures on paralogous genes reveal underappreciated universality of active histone codes adopted across animals.Computational and structural biotechnology journal · 2022Article
- AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation.The Journal of experimental medicine · 2020Article
- Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells.PloS one · 2014Article
- Review
- Histone lysine methylation dynamics: establishment, regulation, and biological impact.Molecular cell · 2012Review
- The STAT3-DNMT1 connection.JAK-STAT · 2012Article
- Review
- Tight associations between transcription promoter type and epigenetic variation in histone positioning and modification.BMC genomics · 2011Article
- Asymmetric cancer cell division regulated by AKT.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle.Oncogene · 2010Article
- Epigenomics of T cell activation, differentiation, and memory.Current opinion in immunology · 2010Review
- Core promoter structure and genomic context reflect histone 3 lysine 9 acetylation patterns.BMC genomics · 2010Article
- Principles and challenges of genomewide DNA methylation analysis.Nature reviews. Genetics · 2010Review
- Genome-scale DNA methylation analysis.Epigenomics · 2010Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated functional epigenetic changes that occur in primary human T lymphocytes during entry into the cell cycle and mapped these at the single-nucleosome level by ChIP-chip on tiling arrays for chromosomes 1 and 6. We show that nucleosome loss and flanking active histone marks define active transcriptional start sites (TSSs). Moreover, these signatures are already set at many inducible genes in quiescent cells prior to cell stimulation. In contrast, there is a dearth of the inactive histone mark H3K9me3 at the TSS, and under-representation of H3K9me2 and H3K9me3 defines the body of active genes. At the DNA level, cytosine methylation (meC) is enriched for nucleosomes that remain at the TSS, whereas in general there is a dearth of meC at TSSs. Furthermore, a drop in meC also marks 3' transcription termination, and a peak of meC occurs at stop codons. This mimics the 3' nucleosomal distribution in yeast, which we show does not occur in human T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.