ArticleMolecular biology and evolution2009
Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- A novel female reproductive organ differentiates insemination and postmating responses in bedbugs.Molecular biology and evolution · 2026Article
- Evolution of the reproductive interactome and the origins of postmating-prezygotic reproductive divergence.BMC biology · 2026Article
- Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation.Cold Spring Harbor perspectives in biology · 2024Review
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- Evolutionary Quantitative Proteomics of Reproductive Protein Divergence in Drosophila.Molecular & cellular proteomics : MCP · 2023Article
- Article
- Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization.Parasites & vectors · 2021Article
- Drosophila female reproductive tract gene expression reveals coordinated mating responses and rapidly evolving tissue-specific genes.G3 (Bethesda, Md.) · 2021Article
- Differences in Postmating Transcriptional Responses between Conspecific and Heterospecific Matings in Drosophila.Molecular biology and evolution · 2021Article
- Pronounced Postmating Response in the Drosophila Female Reproductive Tract Fluid Proteome.Molecular & cellular proteomics : MCP · 2021Article
- Quantitative proteomics reveals rapid divergence in the postmating response of female reproductive tracts among sibling species.Proceedings. Biological sciences · 2020Article
- Genomic analysis of the four ecologically distinct cactus host populations of Drosophila mojavensis.BMC genomics · 2019Article
- Effects of temperature on transcriptome and cuticular hydrocarbon expression in ecologically differentiated populations of desertEcology and evolution · 2017Article
- Proteomics reveals major components of oogenesis in the reproductive tract of sugar-fed Anopheles aquasalis.Parasitology research · 2016Article
- Recurrent specialization on a toxic fruit in an island Drosophila population.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Dynamic digestive physiology of a female reproductive organ in a polyandrous butterfly.The Journal of experimental biology · 2015Article
- Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila.Molecular biology and evolution · 2014Article
- Identification and function of proteolysis regulators in seminal fluid.Molecular reproduction and development · 2013Review
- Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila.Molecular biology and evolution · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Secreted proteases play integral roles in sexual reproduction in a broad range of taxa. In the genetic model Drosophila melanogaster, these molecules are thought to process peptides and activate enzymes inside female reproductive tracts, mediating critical postmating responses. A recent study of female reproductive tract proteins in the cactophilic fruit fly Drosophila arizonae, identified pervasive, lineage-specific gene duplication amongst secreted proteases. Here, we compare the evolutionary dynamics, biochemical nature, and physiological significance of secreted female reproductive serine endoproteases between D. arizonae and its congener D. melanogaster. We show that D. arizonae lower female reproductive tract (LFRT) proteins are significantly enriched for recently duplicated secreted proteases, particularly serine endoproteases, relative to D. melanogaster. Isolated lumen from D. arizonae LFRTs, furthermore, exhibits significant trypsin-like and elastase-like serine endoprotease activity, whereas no such activity is seen in D. melanogaster. Finally, trypsin- and elastase-like activity in D. arizonae female reproductive tracts is negatively regulated by mating. We propose that the intense proteolytic environment of the D. arizonae female reproductive tract relates to the extraordinary reproductive physiology of this species and that ongoing gene duplication amongst these proteases is an evolutionary consequence of sexual conflict.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.