ArticleExperimental parasitology2009
Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.
Article in Experimental parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Prioritization of chemical scaffolds using the TDR Targets database: An integrative workflow for Trypanosoma cruzi drug discovery.PLoS neglected tropical diseases · 2026Article
- An Efficient Method for the Synthesis and In Silico Study of Novel Oxy-Camalexins.Molecules (Basel, Switzerland) · 2025Article
- Anticancer Potential of Indole Phytoalexins and Their Analogues.Molecules (Basel, Switzerland) · 2024Review
- The Versatility in the Applications of Dithiocarbamates.International journal of molecular sciences · 2022Review
- Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.RSC advances · 2021Review
- Synthesis ofNanomaterials (Basel, Switzerland) · 2021Article
- One-pot enantioselective synthesis of (S)-spirobrassinin and non-natural (S)-methylspirobrassinin from amino acids using a turnip enzyme.Journal of natural medicines · 2021Article
- Responses of the Necrotrophic FungusFrontiers in plant science · 2020Article
- Camalexin Induces Apoptosis via the ROS-ER Stress-Mitochondrial Apoptosis Pathway in AML Cells.Oxidative medicine and cellular longevity · 2018Article
- Antiproliferative Effect of Indole Phytoalexins.Molecules (Basel, Switzerland) · 2016Review
- Effects of ferrofluid and phytoalexin spirobrassinin on thioflavin-T-based fluorescence in cerebrospinal fluid of the elderly and multiple sclerosis patients.Neurochemical research · 2014Article
- Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D.Molecules (Basel, Switzerland) · 2014Article
- The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species.Journal of natural medicines · 2013Article
- Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2013Article
- Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9.Journal of natural medicines · 2011Article
- Organocatalytic enantioselective tandem aldol-cyclization reaction of α-isothiocyanato imides and activated carbonyl compounds.Tetrahedron, asymmetry · 2011Article
- High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi.Parasitology international · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
American trypanosomiasis (Chagas disease) continues to be a significant public health problem, and the therapeutic potential of current antichagasic agents (nifurtimox and benznidazole) is rather limited. Here we report on the antitrypanosomal effect of 1-methoxyspirobrassinol and other indole phytoalexins--secondary metabolites produced by Cruciferous plants. These compounds, that previously demonstrated antimicrobial and anticancer properties, displayed significant antiproliferative effects on intracellular amastigotes of Trypanosoma cruzi and may be prospective candidates for antichagasic drug design and development.
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