Trial reportThe international journal of neuropsychopharmacology2009
Subchronic SSRI administration reduces insula response during affective anticipation in healthy volunteers.
Trial report in The international journal of neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00703885 (PharmacofMRI of Anxiolytic Medications), which is not on this map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PharmacofMRI of Anxiolytic Medications (Alprazolam)
Who cites it
35 citing papers in PubMed, 80 citations in OpenAlex.
- A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing.Translational psychiatry · 2025Trial
- Amygdala activity after subchronic escitalopram administration in healthy volunteers: A pharmaco-functional magnetic resonance imaging study.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Acute Neurofunctional Effects of Escitalopram in Pediatric Anxiety: A Double-Blind, Placebo-Controlled Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Trial
- Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study.BMC neurology · 2019Trial
- Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- Effects of citalopram and escitalopram on fMRI response to affective stimuli in healthy volunteers selected by serotonin transporter genotype.Psychiatry research · 2013Trial
- The effects of sertraline on psychopathic traits.International clinical psychopharmacology · 2011Trial
- Neural correlates of antidepressant-related sexual dysfunction: a placebo-controlled fMRI study on healthy males under subchronic paroxetine and bupropion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Pregabalin influences insula and amygdala activation during anticipation of emotional images.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.PloS one · 2011Trial
- Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.PloS one · 2011Trial
- Escitalopram attenuates posterior cingulate activity during self-evaluation in healthy volunteers.Psychiatry research · 2010Trial
- Reduced Trust in Bodily Sensations Predicts Suicidal Ideation in Hospitalized Patients With Major Depression: An Observational Study.Suicide & life-threatening behavior · 2025Observational
- [Therapeutic mechanism of hederagenin, an active component inNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Amygdala-insula response to neutral stimuli and the prospective prediction of anxiety sensitivity.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Touch medicine: bridging the gap between recent insights from touch research and clinical medicine and its special significance for the treatment of affective disorders.Frontiers in psychiatry · 2024Review
- A single oral dose of citalopram increases interoceptive insight in healthy volunteers.Psychopharmacology · 2022Article
- [Touch Medicine - a complementary therapeutic approach exemplified by the treatment of depression].Deutsche medizinische Wochenschrift (1946) · 2022Article
- Transcutaneous auricular vagus nerve immediate stimulation treatment for treatment-resistant depression: A functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
- Selective serotonin reuptake inhibitor treatment retunes emotional valence in primate ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The anterior cingulate cortex (ACC) and insula are important neural substrates for the integration of cognitive, emotional, and physiological information, as well as the coordination of responses to anticipated stimuli. Increased neural activation within these structures has been observed in individuals with anxiety and depressive disorders. Selective serotonin reuptake inhibitors (SSRIs) are among the most effective and frequently prescribed anxiolytic agents, yet it is not known whether ACC or insula underlie the effects of these drugs. We examined whether subchronic administration of a SSRI to healthy volunteers attenuates activation in ACC or insula during anticipation, an important emotional process underlying anxiety. Support for this hypothesis would help to understand where and by what process SSRIs may exert beneficial effects as anxiolytics and would provide further mechanistic evidence for functional magnetic resonance imaging (fMRI) as a biomarker for the development of anxiolytics. Fifteen volunteers participated in a double-blind, placebo-controlled, randomized cross-over study. Participants completed a pleasant and aversive picture-cued anticipation task during fMRI after taking either escitalopram (10 mg) or placebo for 21 d. We found that escitalopram significantly decreased activation in bilateral posterior and middle insula during the anticipation condition irrespective of stimulus valence and in medial prefrontal and ACC during anticipation of aversive vs. pleasant images. Reduced insular and ACC activation in healthy controls during anticipation may be integral to the therapeutic efficacy of SSRIs and may provide a mechanistic approach for the use of pharmaco-fMRI in the identification of novel pharmacotherapeutic agents in patient populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.