ArticleBMC cancer2009
The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors.DNA and cell biology · 2012Article
- Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma.The American journal of surgical pathology · 2011Article
- Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium.The Journal of biological chemistry · 2011Article
- Molecular mechanisms of ETS transcription factor-mediated tumorigenesis.Critical reviews in biochemistry and molecular biologyReview
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3 authors at 1 institution in 1 country.
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Abstract
backgroundEts transcription factors have been widely implicated in the control of tumorigenesis, with most studies suggesting tumor-promoting roles. However, few studies have examined Ets tumorigenesis-modifying functions in vivo using model genetic systems.
methodsUsing mice expressing a previously characterized Ets dominant repressor transgene in the intestinal epithelium (Villin-En/Erm), we examined the consequences of blocking endogenous Ets-mediated transcriptional activation on tumorigenesis in the ApcMin model of intestinal carcinoma.
resultsEn/Erm expression in the intestine, at levels not associated with overt crypt-villus dysmorphogenesis, results in a marked increase in tumor number in ApcMin animals. Moreover, when examined histologically, tumors from En/Erm-expressing animals show a trend toward greater stromal invasiveness. Detailed analysis of crypt-villus homeostasis in these En/Erm transgenic animals suggests increased epithelial turnover as one possible mechanism for the enhanced tumorigenesis.
conclusionOur findings provide in vivo evidence for a tumor-restricting function of endogenous Ets factors in the intestinal epithelium.
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