ArticleBMC neuroscience2009
In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain.
Article in BMC neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection.PloS one · 2012Trial
- Combination antiretroviral therapy prevents SIV-induced aging in the hippocampus and neurodegeneration throughout the brain.Journal of neurovirology · 2025Article
- Review
- Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS.Pathogens (Basel, Switzerland) · 2021Review
- Regional Brain Recovery from Acute Synaptic Injury in Simian Immunodeficiency Virus-Infected Rhesus Macaques Associates with Heme Oxygenase Isoform Expression.Journal of virology · 2020Article
- Low-frequency fluctuation characteristics in rhesus macaques with SIV infection: a resting-state fMRI study.Journal of neurovirology · 2019Article
- Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice.Molecular neurobiology · 2016Article
- Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection.The Journal of infectious diseases · 2015Article
- A longitudinal magnetization transfer imaging evaluation of brain injury in a macaque model of neuroAIDS.AIDS research and human retroviruses · 2015Article
- Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogens.Molecular imaging and biology · 2015Review
- Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice.Molecular neurodegeneration · 2014Article
- Longitudinal cerebral metabolic changes in pig-tailed macaques infected with the neurovirulent virus SIVsmmFGb.Journal of neurovirology · 2014Article
- Imaging neuroinflammation? A perspective from MR spectroscopy.Brain pathology (Zurich, Switzerland) · 2014Article
- Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection.Neurology · 2014Article
- Glutamate metabolism and HIV-associated neurocognitive disorders.Journal of neurovirology · 2014Review
- HIV-1, HCV and alcohol in the CNS: potential interactions and effects on neuroinflammation.Current HIV research · 2014Review
- Cerebrospinal fluid and neuroimaging biomarker abnormalities suggest early neurological injury in a subset of individuals during primary HIV infection.The Journal of infectious diseases · 2013Article
- Global gray and white matter metabolic changes after simian immunodeficiency virus infection in CD8-depleted rhesus macaques: proton MRS imaging at 3 T.NMR in biomedicine · 2013Article
- Quantitative MRI Measures in SIV-Infected Macaque Brains.Journal of clinical & cellular immunology · 2013Article
- Early detection of simian immunodeficiency virus in the central nervous system following oral administration to rhesus macaques.Frontiers in immunology · 2013Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundIn vivo proton magnetic resonance spectroscopy (1H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection.
resultsChanges in the N-acetylaspartate (NAA), choline (Cho), myo-inositol (MI), creatine (Cr) and glutamine/glutamate (Glx) resonances were quantified both in absolute terms and relative to the creatine resonance. Most abnormalities were observed at the time of peak viremia, 2 weeks post infection (wpi). At that time point, significant decreases in NAA and NAA/Cr, reflecting neuronal injury, were observed only in the frontal cortex. Cr was significantly elevated only in the white matter. Changes in Cho and Cho/Cr were similar across the brain regions, increasing at 2 wpi, and falling below baseline levels at 4 wpi. MI and MI/Cr levels were increased across all brain regions.
conclusionThese data best support the hypothesis that different brain regions have variable intrinsic vulnerabilities to neuronal injury caused by the AIDS virus.
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