ArticleBMC bioinformatics2009
Modeling the role of p53 pulses in DNA damage- induced cell death decision.
Article in BMC bioinformatics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes.Genes · 2024Article
- Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress.Molecular systems biology · 2022Article
- Modeling of DNA Damage Repair and Cell Response in Relation to p53 System Exposed to Ionizing Radiation.International journal of molecular sciences · 2022Article
- Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway.Journal of Zhejiang University. Science. B · 2021Article
- Dual roles of SIRT1 in the BAX switch through the P53 module: A mathematical modeling study.Computational and structural biotechnology journal · 2021Article
- Protein stability of p53 targets determines their temporal expression dynamics in response to p53 pulsing.The Journal of cell biology · 2019Article
- Recent progress and open challenges in modeling p53 dynamics in single cells.Current opinion in systems biology · 2017Article
- Bifurcation in Cell Cycle Dynamics Regulated by p53.PloS one · 2015Article
- The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.BMC biology · 2013Article
- Article
- Mechanisms that enhance sustainability of p53 pulses.PloS one · 2013Article
- Rigor of cell fate decision by variable p53 pulses and roles of cooperative gene expression by p53.Biophysics (Nagoya-shi, Japan) · 2012Article
- PDCD5-regulated cell fate decision after ultraviolet-irradiation-induced DNA damage.Biophysical journal · 2011Article
- Article
- Modeling the basal dynamics of p53 system.PloS one · 2011Article
- Coordination of the nuclear and cytoplasmic activities of p53 in response to DNA damage.Biophysical journal · 2010Article
- Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system.Biophysical journal · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe tumor suppressor p53 plays pivotal roles in tumorigenesis suppression. Although oscillations of p53 have been extensively studied, the mechanism of p53 pulses and their physiological roles in DNA damage response remain unclear.
resultsTo address these questions we presented an integrated model in which Ataxia-Telangiectasia Mutated (ATM) activation and p53 oscillation were incorporated with downstream apoptotic events, particularly the interplays between Bcl-2 family proteins. We first reproduced digital oscillation of p53 as the response of normal cells to DNA damage. Subsequent modeling in mutant cells showed that high basal DNA damage is a plausible cause for sustained p53 pulses observed in tumor cells. Further computational analyses indicated that p53-dependent PUMA accumulation and the PUMA-controlled Bax activation switch might play pivotal roles to count p53 pulses and thus decide the cell fate.
conclusionThe high levels of basal DNA damage are responsible for generating sustained pulses of p53 in the tumor cells. Meanwhile, the Bax activation switch can count p53 pulses through PUMA accumulation and transfer it into death signal. Our modeling provides a plausible mechanism about how cells generate and orchestrate p53 pulses to tip the balance between survival and death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.