ArticleMedical physics2009
An MRI-compatible system for focused ultrasound experiments in small animal models.
Article in Medical physics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 95 citations in OpenAlex.
- MRI guided HIFU robotic system application in feasibility study for treating uterine fibroids.Scientific reports · 2025Article
- Preclinical robotic device for magnetic resonance imaging guided focussed ultrasound.The international journal of medical robotics + computer assisted surgery : MRCAS · 2023Article
- Comparison of Sonication Patterns and Microbubble Administration Strategies for Focused Ultrasound-Mediated Large-Volume Drug Delivery.IEEE transactions on bio-medical engineering · 2022Article
- An Affordable and Easy-to-Use Focused Ultrasound Device for Noninvasive and High Precision Drug Delivery to the Mouse Brain.IEEE transactions on bio-medical engineering · 2022Article
- Acoustic Holograms for Bilateral Blood-Brain Barrier Opening in a Mouse Model.IEEE transactions on bio-medical engineering · 2022Article
- Numerical Evaluation of the Effects of Transducer Displacement on Transcranial Focused Ultrasound in the Rat Brain.Brain sciences · 2022Article
- Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma.Scientific reports · 2021Article
- Magnetic Resonance Imaging-Guided Focused Ultrasound Positioning System for Preclinical Studies in Small Animals.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021Article
- Stereotactic Transcranial Focused Ultrasound Targeting System for Murine Brain Models.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Focused ultrasound robotic system for very small bore magnetic resonance imaging.The international journal of medical robotics + computer assisted surgery : MRCAS · 2020Article
- Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia.Theranostics · 2020Article
- MRI-guided robotic arm drives optogenetic fMRI with concurrent CaNature communications · 2019Article
- Magnetocaloric materials as switchable high contrast ratio MRI labels.Magnetic resonance in medicine · 2019Article
- MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control.Scientific reports · 2018Article
- An MRI-compatible platform for one-dimensional motion management studies in MRI.Magnetic resonance in medicine · 2016Article
- Development of a spherically focused phased array transducer for ultrasonic image-guided hyperthermia.Physics in medicine and biology · 2016Article
- Gene delivery to the spinal cord using MRI-guided focused ultrasound.Gene therapy · 2015Article
- Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents.Journal of therapeutic ultrasound · 2015Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The development of novel MRI-guided therapeutic ultrasound methods including potentiated drug delivery and targeted thermal ablation requires extensive testing in small animals such as rats and mice due to the widespread use of these species as models of disease. An MRI-compatible, computer-controlled three-axis positioning system was constructed to deliver focused ultrasound exposures precisely to a target anatomy in small animals for high-throughput preclinical drug delivery studies. Each axis was constructed from custom-made nonmagnetic linear ball stages driven by piezoelectric actuators and optical encoders. A range of motion of 5 x 5 x 2.5 cm3 was achieved, and initial bench top characterization demonstrated the ability to deliver ultrasound to the brain with a spatial accuracy of 0.3 mm. Operation of the positioning system within the bore of a clinical 3 T MR imager was feasible, and simultaneous motion and MR imaging did not result in any mutual interference. The system was evaluated in its ability to deliver precise sonications within the mouse brain, linear scanned exposures in a rat brain for blood barrier disruption, and circular scans for controlled heating under MR temperature feedback. Initial results suggest that this is a robust and precise apparatus for use in the investigation of novel ultrasound-based therapeutic strategies in small animal preclinical models.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.