ArticleStem cells (Dayton, Ohio)2009
Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation.
Article in Stem cells (Dayton, Ohio), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Dysregulation of inflammasome activation in glioma.Cell communication and signaling : CCS · 2023Review
- Non-neoplastic astrocytes: key players for brain tumor progression.Frontiers in cellular neuroscience · 2023Review
- Abrogation of Rb Tumor Suppression Initiates GBM in Differentiated Astrocytes by Driving a Progenitor Cell Program.Frontiers in oncology · 2022Article
- Adult neurogenesis from reprogrammed astrocytes.Neural regeneration research · 2020Review
- The Role of SVZ Stem Cells in Glioblastoma.Cancers · 2019Review
- Glioblastoma: Microenvironment and Niche Concept.Cancers · 2018Review
- Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?Oncotarget · 2017Review
- Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation.Journal of cancer research and clinical oncology · 2015Review
- Data in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study.Data in brief · 2015Article
- Cell of origin for malignant gliomas and its implication in therapeutic development.Cold Spring Harbor perspectives in biology · 2015Review
- Cell transcriptional state alters genomic patterns of DNA double-strand break repair in human astrocytes.Nature communications · 2014Article
- On the origin of glioma.Upsala journal of medical sciences · 2012Article
- Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.Cancer cell · 2011Article
- Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors.PloS one · 2011Article
- Article
- The bright and the dark sides of DNA repair in stem cells.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. Transforming growth factor (TGF)-alpha, an epidermal growth factor family member, is frequently overexpressed in the early stages of glioma progression. We previously demonstrated that prolonged exposure of astrocytes to TGF-alpha is sufficient to trigger their reversion to a neural progenitor-like state. To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes. We show that these cells had the same cytogenomic profile as astrocytes, survived in vivo, and did not give birth to tumors. When astrocytes dedifferentiated with TGF-alpha were submitted to oncogenic stress using gamma irradiation, they acquired cancerous properties: they were immortalized, showed cytogenomic abnormalities, and formed high-grade glioma-like tumors after brain grafting. In contrast, irradiation did not modify the lifespan of astrocytes cultivated in serum-free medium. Addition of TGF-alpha after irradiation did not promote their transformation but decreased their lifespan. These results demonstrate that reversion of mature astrocytes to an embryonic state without genomic manipulation is sufficient to sensitize them to oncogenic stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.